Cannabinoids May Inhibit Cancer Cell Invasion

This is preliminary stuff but it looks interesting

Cannabinoids may suppress tumor invasion in highly invasive cancers, according to a study published online December 25 in the Journal of the National Cancer Institute. Cannabinoids, the active components in marijuana, are used to reduce the side effects of cancer treatment, such as pain, weight loss, and vomiting, but there is increasing evidence that they may also inhibit tumor cell growth. However, the cellular mechanisms behind this are unknown.

Robert Ramer, Ph.D., and Burkhard Hinz, Ph.D., of the University of Rostock in Germany investigated whether and by what mechanism cannabinoids inhibit tumor cell invasion. Cannabinoids did suppress tumor cell invasion and stimulated the expression of TIMP-1, an inhibitor of a group of enzymes that are involved in tumor cell invasion.

"To our knowledge, this is the first report of TIMP-1-dependent anti-invasive effects of cannabinoids. This signaling pathway may play an important role in the antimetastatic action of cannabinoids, whose potential therapeutic benefit in the treatment of highly invasive cancers should be addressed in clinical trials," the authors write.

Source




The evils of caffeine!

A few years ago, we ordered a fine saltwater fishing reel from a fine specialty sporting goods purveyor in California. It arrived in fine condition, in a fine box listing attributes that would turn the angler into a fisherperson of superhuman ability. The box, however, was marred by a hideous, scary sticker warning that the product therein contained, by the findings of the most oppressive nanny state in the history of the world (the aforementioned California), could cause cancer to ourselves, our loved ones and our unborn, yea unto generations. A fishing reel? Well, no, not the reel itself, but the oil the manufacturer had diligently but sparingly applied so as to improve the efficiency of precision machined parts and bearings.

That warning, and literally millions of others like it, resulted from California's Proposition 65, a 1986 initiative authored by the infamous Tom Hayden that has turned California into the warning label capital of the world, worrying more about driplets of this and droplets of that than mudslides, fires and earthquakes that really do pose consequential dangers to Californians in their lifetimes. Now it's caffeine in the Prop 65 crosshairs. On December 10, California's "Office of Environmental Health Hazard Assessment's Developmental and Reproductive Toxicant Identification Committee" (we kid you not as to the name) voted 4 to 3 to add caffeine to a new list for review, which will take about a year, and possible inclusion on the Prop 65 warning list.

Well, what could be wrong with that, health-conscious citizens will undoubtedly ask. Let's start with the fact, largely and conveniently ignored by most nannies including those with advanced degrees, that the very foundation of toxicology (first enunciated by Paracelsus, the father of toxicology) is "the dose makes the poison." That applies to every substance, natural or man-made, which humans ingest or to which we are exposed. Water and arsenic will both kill you dead, but neither in the "doses" to which most humans are exposed.

Caffeine has been studied as many times as almost all other potentially dangerous substances and found to pose no risks (and provide some benefits) when used in moderation. That means it is probably not conscientious to buy a Starbucks card for an infant, but for most of us, we are not "dosing" to any deleterious level, and "at-risk" individuals would be much better advised to consult physicians rather than the state of California. The real kicker, typically Californian, is that if caffeine is added to the Prop 65 warning list, the warnings will not apply to coffee or tea, of which caffeine is a natural component, from which most caffeine is consumed, but only to prepared drinks in which caffeine is part of the formula. That makes sense in no known scientific or health context, but only in the context of political correctness so out of control that it, in and of itself, is a danger.

Not to be outdone by the state, San Francisco Mayor Gavin Newsom intends to try to tax sales of soft drinks sweetened with high-fructose corn syrup (one of the latest demons being mined by junk science proponents). The stated rationale is the rate of childhood obesity in San Francisco. The tax will not, however, be applied to all sales of such beverages across the board, but only to "big box retailers," something only a moral titan like Newsom could dream up.

It's for the kids, but how many kids do you know who go running into Sam's Club or Costco after school for their soda, considering that the smallest unit sold by the big boxers is a week's supply for a family of eight. The corner store, with infinitely more individual sales more frequently directly to the so-called population at risk, skates on the tax.

Punitive, discriminatory and self-defeating hypocrisy, with big tax bucks the only objective? Absolutely. It's also just politics as usual for a new breed of politicians so cynical as to not even bother to make their stories plausible. But all that is to be expected. The sheeple (great word, author unknown) of California, San Francisco or anywhere else who roll over for this nonsense are the ones who really need to take a look in the mirror.

Source

****************

Just some problems with the "Obesity" war:

1). It tries to impose behavior change on everybody -- when most of those targeted are not obese and hence have no reason to change their behaviour. It is a form of punishing the innocent and the guilty alike. (It is also typical of Leftist thinking: Scorning the individual and capable of dealing with large groups only).

2). The longevity research all leads to the conclusion that it is people of MIDDLING weight who live longest -- not slim people. So the "epidemic" of obesity is in fact largely an "epidemic" of living longer.

3). It is total calorie intake that makes you fat -- not where you get your calories. Policies that attack only the source of the calories (e.g. "junk food") without addressing total calorie intake are hence pissing into the wind. People involuntarily deprived of their preferred calorie intake from one source are highly likely to seek and find their calories elsewhere.

4). So-called junk food is perfectly nutritious. A big Mac meal comprises meat, bread, salad and potatoes -- which is a mainstream Western diet. If that is bad then we are all in big trouble.

5). Food warriors demonize salt and fat. But we need a daily salt intake to counter salt-loss through perspiration and the research shows that people on salt-restricted diets die SOONER. And Eskimos eat huge amounts of fat with no apparent ill-effects. And the average home-cooked roast dinner has LOTS of fat. Will we ban roast dinners?

6). The foods restricted are often no more calorific than those permitted -- such as milk and fruit-juice drinks.

7). Tendency to weight is mostly genetic and is therefore not readily susceptible to voluntary behaviour change.

8). And when are we going to ban cheese? Cheese is a concentrated calorie bomb and has lots of that wicked animal fat in it too. Wouldn't we all be better off without it? And what about butter and margarine? They are just about pure fat. Surely they should be treated as contraband in kids' lunchboxes! [/sarcasm].

9). And how odd it is that we never hear of the huge American study which showed that women who eat lots of veggies have an INCREASED risk of stomach cancer? So the official recommendation to eat five lots of veggies every day might just be creating lots of cancer for the future! It's as plausible (i.e. not very) as all the other dietary "wisdom" we read about fat etc.

10). And will "this generation of Western children be the first in history to lead shorter lives than their parents did"? This is another anti-fat scare that emanates from a much-cited editorial in a prominent medical journal that said so. Yet this editorial offered no statistical basis for its opinion -- an opinion that flies directly in the face of the available evidence.

Even statistical correlations far stronger than anything found in medical research may disappear if more data is used. A remarkable example from Sociology:

"The modern literature on hate crimes began with a remarkable 1933 book by Arthur Raper titled The Tragedy of Lynching. Raper assembled data on the number of lynchings each year in the South and on the price of an acre's yield of cotton. He calculated the correlation coefficient between the two series at -0.532. In other words, when the economy was doing well, the number of lynchings was lower.... In 2001, Donald Green, Laurence McFalls, and Jennifer Smith published a paper that demolished the alleged connection between economic conditions and lynchings in Raper's data. Raper had the misfortune of stopping his analysis in 1929. After the Great Depression hit, the price of cotton plummeted and economic conditions deteriorated, yet lynchings continued to fall. The correlation disappeared altogether when more years of data were added."

So we must be sure to base our conclusions on ALL the data. But in medical research, data selectivity and the "overlooking" of discordant research findings is epidemic.

*********************

Why I've no appetite for the Fife Diet

A 'small, grassroots movement' has sprung up in Scotland based on eating only food produced nearby. Local boy James Panton is appalled.



Burntisland is a picturesque town on the banks of the River Forth in east Scotland. It is home to the Fife Diet, the latest eco-trend, in which people are attempting to minimize their `carbon footprint' by living only on food that has been grown or produced in Fife. I grew up in Burntisland and lived for the first few years of my life on an enforced `Fife diet' - and I find the idea of eating nothing but local produce appalling.

The Fife diet, at least the one I vaguely remember from childhood, seemed to consist of an awful lot of mince with neeps and tatties (turnip and potatoes), stovies (bacon or corned beef with potatoes and onions) and stews (made of god-knows-what, but there were definitely potatoes involved). My mother was an immigrant from Nottingham in the English midlands, so she knew of culinary possibilities that existed beyond the Firth of Forth and she worked hard to educate my dad's rather conservative tastebuds.

Once a week, she would slip in a spaghetti bolognese, which Dad approved of as sufficiently mince-based, although to this day he cuts up his spaghetti with a knife and fork and is suspicious of parmesan. One of my sisters was a dab hand at quiche lorraine (or egg and bacon flan with exotic aspirations). A couple of times a year we had food from the Chinese takeaway on the High Street. Traditional Scottish egg foo yung, which I remember bearing remarkable similarities to scrambled egg with peas and onions, was a favourite. I know for a fact that we had a fondue set, but it was never used in front of the children.

I suspect that my early childhood diet wasn't that different to many people with my kind of Scottish small-ish town background in the late Seventies and early Eighties. We weren't particularly conservative, but the menu was pretty traditional, based on ingredients that had been used for decades and cooked in the same old ways. More interesting ingredients and ways of cooking were available: Edinburgh was just over 30 minutes away on the train and it was home to fruit and veg shops selling exotica of all shapes and sizes; there were Italian delicatessens with cheeses that came in a wider range than `red cheese' and `yellow cheese', and there were general stores that smelt of Indian spices and even Chinese supermarkets if you knew where to look. The foods from such specialist shops weren't part of my daily diet, though - they were expensive treats and curiosities, not daily staples, and they weren't generally available down in our local Co-op store.

Since I left Burntisland and moved to London at the age of 18, my daily diet has changed beyond all recognition. But what is remarkable is that so too has the daily diet of my parents and my older brothers and sisters who still live in or around Burntisland. Things that were once exotic are now commonplace in the supermarket and even at the Co-op: shipped and flown from around the world in bulk, they are available at a price that makes them affordable as everyday grub.

So there is something depressing about the news that Burntisland is now home to what the Guardian has called a `small grassroots movement' (1) (note the radical twang) that thinks the way to make the world a better place is to eat only foods that have been grown in the region of Fife. Inspired by the Vancouver-based 100 Mile Diet (2), in which participants attempted to survive on food produced within 100 miles of their homes, the Fife Diet draws its ingredients from an even smaller area of land. The diet is premised on the notion that reducing the number of `food miles' (the miles travelled by the food we eat between production and consumption) is one of the most important contributions individuals can make to saving the planet.

Mike Small, the inspiration behind the diet, claims that this is `not a back-to-nature movement rejecting the twenty-first century. It is a flexible, consciousness-raising exercise to show what realistic changes individuals can make'. He is surely right - the Fife Diet is a product of a peculiarly twenty-first century form of moralistic miserliness where the future of the planet is understood to be dependent upon the consumption choices made by individual families. The more they can reject the advances of food production and transportation that the late twentieth century brought to small towns like Burntisland the better.

The Fife Diet is celebrated as a way of bringing local communities together and supporting local producers and their products against `the ecological insanity of transporting food around the world' (3). Implicit in this is a politically correct kind of economic protectionism which seeks to celebrate everything local in opposition to producers from other parts of the world. Although I'm a fan of Burntisland, and I have many friends in Fife, I'm not convinced that its small farmers are any more deserving than the rather more efficient producers in many other parts of the world.

According to the diet's website `It's no good just saying no. We can't just oppose Tesco, rage against food miles and rant against food-packaging. In all aspects of socio-ecology we need to build alternative platforms and movements from within the shell of the old decaying society' (4). Unlike the 19 families who have so far signed up to the Fife Diet, I'm not at all convinced that having a diet so exotic as to include such luxuries as salt and pepper, tea and coffee and even the occasional glass of wine - all of which are ruled out in the Fife Diet in an attempt to curb climate change - is an expression of social decay. On the contrary, these foodstuffs were even part of the rather limited diet of my family when I was a young child.

And I am certainly not convinced that Tesco and other supermarket chains are the source of social decay. In fact, they are the means by which everyone from London to Burntisland can get hold of cheaply produced and distributed food from around the world - and all a damned sight more interesting than the neeps and tatties of my youth. The Fife Diet may be regarded as radical by those with low horizons, but attempting to solve the world's problems by retreating to the local shows that such campaigners are starved of imagination.

Source





In praise of McDonald's

To gauge this pell-mell nation's velocity, visit here with Jim Skinner, chief executive officer of a company on pace to have a net income for 2007 of $3.46 billion, up 12.7 percent, on revenues of almost $23 billion. The evolution of McDonald's mirrors that of the nation in which it serves 27 million customers a day.

Americans commonly say this or that distinction is "as clear as night and day." Americans, ricocheting around the country around the clock, are erasing the distinction between night and day. Breakfast, the meal most apt to be eaten at home, now accounts for more than 25 percent of U.S. business for McDonald's. More than 90 percent of its restaurants have extended hours - beyond the regular 6 a.m. through 10 p.m. - and about 35 percent are open 24 hours a day, seven days a week, up from less than 10 percent just five years ago.

America is in the third era since its meals began to mirror its mobility. First came the Steak 'n Shake Era. That restaurant chain began downstate in 1934, in the perfectly named town of Normal, Ill., as Americans were getting used to eating out. They were leery of food that came from a kitchen they could not see, so Steak 'n Shake put its grills behind glass in full view and adopted the slogan "In sight it must be right."

In 1955, when Ray Kroc launched the McDonald's Era, Americans were doing what Dinah Shore urged them to do, seeing the U.S.A. in their Chevrolets, seeking novel experiences - but not in food. When they got out of their cars for nourishment, they wanted no surprises. Hence the rise of franchising - the same food here, there and, eventually, everywhere.

Now we are in the Snack Wrap Era. Last year McDonald's started selling chicken and other stuff wrapped in tortillas. This product was a response to consumer appetites for something to eat between meals and with one hand on the steering wheel. More and more Americans do not want to get out of their cars: Most of America's McDonald's have drive-through windows, and most of these restaurants sell most of their food through those windows.

McDonald's exemplifies the role of small businesses in Americans' upward mobility. The company is largely a confederation of small businesses: 85 percent of its U.S. restaurants - average annual sales, $2.2 million - are owned by franchisees. McDonald's has made more millionaires, and especially black and Hispanic millionaires, than any other economic entity ever, anywhere.

McDonald's has 14,000 restaurants in America, another 17,000 in 117 other countries. The company will add another 1,000 in 2008, more than 90 percent of them abroad. Such is the power of the McDonald's brand, 48 percent of the people of India were aware of McDonald's before it opened its first restaurant on the subcontinent.

Skinner's job is to maximize shareholder value. Shareholders should be pleased. The value of their stock has more than doubled during his three-year tenure. McDonald's stock will have either the best or second-best (if second, only to Merck & Co.) gain among the Dow industrials this year.

The food fascists are not pleased. Pursing their lips and waxing censorious at the mere mention of McDonald's, they blame it for fat people. But although it might seem peculiar to cite McDonald's customers as evidence of Americans' increasing health consciousness, consider this: Red meat has become suspect and McDonald's now sells as much chicken as beef - 150 percent more chicken in dollar volume than just five years ago.

Do the arithmetic, says Skinner. Americans eat 90 meals a month. The average American, who has 900,000 restaurants to choose from, eats three of those meals at McDonald's. Surely the other 87 meals are more of a problem. Even McDonald's core customers, who eat there 50 times a year, consume more than 1,000 meals elsewhere.

Although its core products remain hamburgers, fries and milkshakes, it sells a lot of salads to the 52 million customers it has every day worldwide. Kroc, who died in 1984, once said he did not know what his company would be selling in 2000 but he knew it would be selling more of it than anyone else. He was right.

Source

****************

Just some problems with the "Obesity" war:

1). It tries to impose behavior change on everybody -- when most of those targeted are not obese and hence have no reason to change their behaviour. It is a form of punishing the innocent and the guilty alike. (It is also typical of Leftist thinking: Scorning the individual and capable of dealing with large groups only).

2). The longevity research all leads to the conclusion that it is people of MIDDLING weight who live longest -- not slim people. So the "epidemic" of obesity is in fact largely an "epidemic" of living longer.

3). It is total calorie intake that makes you fat -- not where you get your calories. Policies that attack only the source of the calories (e.g. "junk food") without addressing total calorie intake are hence pissing into the wind. People involuntarily deprived of their preferred calorie intake from one source are highly likely to seek and find their calories elsewhere.

4). So-called junk food is perfectly nutritious. A big Mac meal comprises meat, bread, salad and potatoes -- which is a mainstream Western diet. If that is bad then we are all in big trouble.

5). Food warriors demonize salt and fat. But we need a daily salt intake to counter salt-loss through perspiration and the research shows that people on salt-restricted diets die SOONER. And Eskimos eat huge amounts of fat with no apparent ill-effects. And the average home-cooked roast dinner has LOTS of fat. Will we ban roast dinners?

6). The foods restricted are often no more calorific than those permitted -- such as milk and fruit-juice drinks.

7). Tendency to weight is mostly genetic and is therefore not readily susceptible to voluntary behaviour change.

8). And when are we going to ban cheese? Cheese is a concentrated calorie bomb and has lots of that wicked animal fat in it too. Wouldn't we all be better off without it? And what about butter and margarine? They are just about pure fat. Surely they should be treated as contraband in kids' lunchboxes! [/sarcasm].

9). And how odd it is that we never hear of the huge American study which showed that women who eat lots of veggies have an INCREASED risk of stomach cancer? So the official recommendation to eat five lots of veggies every day might just be creating lots of cancer for the future! It's as plausible (i.e. not very) as all the other dietary "wisdom" we read about fat etc.

10). And will "this generation of Western children be the first in history to lead shorter lives than their parents did"? This is another anti-fat scare that emanates from a much-cited editorial in a prominent medical journal that said so. Yet this editorial offered no statistical basis for its opinion -- an opinion that flies directly in the face of the available evidence.

Even statistical correlations far stronger than anything found in medical research may disappear if more data is used. A remarkable example from Sociology:

"The modern literature on hate crimes began with a remarkable 1933 book by Arthur Raper titled The Tragedy of Lynching. Raper assembled data on the number of lynchings each year in the South and on the price of an acre's yield of cotton. He calculated the correlation coefficient between the two series at -0.532. In other words, when the economy was doing well, the number of lynchings was lower.... In 2001, Donald Green, Laurence McFalls, and Jennifer Smith published a paper that demolished the alleged connection between economic conditions and lynchings in Raper's data. Raper had the misfortune of stopping his analysis in 1929. After the Great Depression hit, the price of cotton plummeted and economic conditions deteriorated, yet lynchings continued to fall. The correlation disappeared altogether when more years of data were added."

So we must be sure to base our conclusions on ALL the data. But in medical research, data selectivity and the "overlooking" of discordant research findings is epidemic.

*********************

Black breast cancer is different

Those pesky genes again

African-American women diagnosed with breast cancer in their mid-30s or younger appear to be more likely than most other women to have a genetic predisposition for the disease, new research suggests. The study, published today in The Journal of the American Medical Association, is one of the first to examine the prevalence of mutations in the tumor suppressor gene BRCA1 by ethnic group in breast cancer patients with and without a family history of breast cancer. According to one estimate, nearly two out of three women who have the BRCA1 mutations are likely to develop breast cancer by age 70.

While African-American women as a group had a lower prevalence of BRCA1 mutations than most white and Hispanic women in the study, African-American women diagnosed with breast cancer before age 35 were roughly twice as likely to carry the mutations. If confirmed in larger studies, this finding could help explain why African-Americans tend to develop more aggressive and deadly breast cancers than other racial groups, says researcher Esther M. John, PhD, of the Northern California Cancer Center. "For whatever reason, African-American women are less likely to be tested [for BRCA mutations] than white women," John tells WebMD. "One message to clinicians might be that they should probably be tested more often."

The study included female breast cancer patients -- younger than age 65 at diagnosis -- enrolled in a California breast cancer registry between 1996 and 2005. Researchers confirmed a high prevalence of BRCA1 mutations among women of Ashkenazi Jewish ancestry, with 8.3% of these patients carrying the mutations compared to 3.5% of Hispanic women, 2.2% of non-Hispanic white women, 1.3% of African-American women, and 0.5% of Asian-American women.

Not surprisingly, BRCA1 mutations were more common in women with a family history of breast or ovarian cancer and less common in breast cancer patients diagnosed later in life. Roughly 17% of African-American patients diagnosed with breast cancer prior to age 35 carried a BRCA1 mutation, compared to 8.9% of Hispanic patients, 7.2% of non-white Hispanics without Ashkenazi Jewish ancestry, and 2.4% of Asian-American patients.

Larger studies are needed to confirm the findings, John says, because of the small number of young breast cancer patients enrolled in the study. Just 30 of the 341 African-American study participants were younger than 35, and five of them tested positive for BRCA1 mutations. John and colleagues conclude that a better understanding of the expression of BRCA mutations among different racial and ethnic groups will help doctors better identify women who should be screened.

In an accompanying editorial, Dezheng Huo, MD, PhD, and Olufunmilayo Olopade, MD, of the University of Chicago call the study by John and colleagues "a good starting point for narrowing the knowledge gap in characterizing the BRCA1 gene." Olopade tells WebMD that minority and other medically underserved women undergo genetic testing for BRCA mutations at a much lower rate than white women. She and Huo write that it is important "to design and evaluate interventions for improving genetic testing uptake in underserved populations, so that genetic testing can achieve full potential as a tool for effective cancer control and prevention."

Source





A bad year to be fat in Britain

The year kicked off with the news that an overweight boy from North Tyneside could be taken from his mother by child protection officials. Her apparent crime: overfeeding her son. He was allowed to stay at home, but in the months to come various investigations - including one by the BBC - would uncover that obesity had been a factor in perhaps as many as two dozen child protection cases.

Some professionals said allowing a child to become obese had to be viewed as a form of neglect, given the potential health consequences. Others believed that to treat childhood obesity as a parental crime was foraying into unchartered - and potentially rather sinister - territory.

Other obesity-related headlines rolled in thick and fast. From fire chiefs considering charging to move large people from their homes to government equating obesity with climate change, fatness was never far away. "When we first started talking about obesity as a problem, it was very hard to be heard," says Dr Ian Campbell, medical director of the charity Weight Concern. "Now the pendulum has swung too far the other way - we hear nothing but. And the net result is that the kind of moralising the obese and overweight have always suffered has somehow become institutionalised."

One of the recent developments that particularly concerns the National Obesity Forum (NOF) is the move towards what has been described as "rationing" healthcare for the obese. According to one tally, there are at least eight NHS trusts which have introduced some form of restriction for non-urgent operations on the overweight. Such measures, which range from patients having to prove they have tried to lose weight to straightforward refusal to refer those above a certain BMI (body mass index), received something of an endorsement from then health secretary Patricia Hewitt earlier this year.

The fact is, doctors say, there are sound clinical reasons to delay treatment until patients lose weight. The operation is likely to be more successful, the recovery time shorter. But Dr Colin Waine, NOF chairman, believes that the obese are simply being used by hospitals as a convenient way to cut down on expenditure. "This is really about resources. You can't argue that denying a hip-and-knee operation to an obese person is in their interests, as it may well be the inability to walk about and exercise which is making their problems worse."

Recently the British Fertility Society has joined in, arguing that the obese should be barred from IVF as extra weight put the health and welfare of both mother and baby at risk. This, Dr Waine claims, is "discriminatory".

And the constant debate about the problems fat people pose can get very tiresome for those on the receiving end. "There's always been prejudice," says Vicki Swinden, founder of Fat Is The New Black. "But what's changed is that this now seems to be totally acceptable. It's perfectly legitimate now for a person standing in an airline queue to say: 'I'm not sitting next to that person, they're too fat.'" Fat Is The New Black argues that being fat does not necessarily mean you are not fit, or prone to ill health, and indeed this stance has been backed up by several studies. Most recently, a major US investigation found the overweight had no higher risk of dying of cancer or heart disease and overall lived longer than those of a "normal" weight.

Yet no-one seriously contends that obesity is not a problem - even if there is debate as to how great a risk it poses. But there is suggestion that perhaps we are harping on too much about it. "It's got to a stage now where it's actually hard to get any useful messages across because people have heard so much, often contradictory, information, that they just think: obesity blah blah blah," says Mrs Swinden.

The Health Secretary Alan Johnson recently said obesity was a problem "on the scale of climate change". Increasingly there are fears that we hear so much about the doom and gloom of global warming that we have started to switch off. "We don't want this to happen with obesity. We know what the problem is. We don't need more reports, more studies, more talking," says Dr Waine. "We just need to get with it now: the government, the food industry, the community and the individual - we need to get cracking."

Source

****************

Just some problems with the "Obesity" war:

1). It tries to impose behavior change on everybody -- when most of those targeted are not obese and hence have no reason to change their behaviour. It is a form of punishing the innocent and the guilty alike. (It is also typical of Leftist thinking: Scorning the individual and capable of dealing with large groups only).

2). The longevity research all leads to the conclusion that it is people of MIDDLING weight who live longest -- not slim people. So the "epidemic" of obesity is in fact largely an "epidemic" of living longer.

3). It is total calorie intake that makes you fat -- not where you get your calories. Policies that attack only the source of the calories (e.g. "junk food") without addressing total calorie intake are hence pissing into the wind. People involuntarily deprived of their preferred calorie intake from one source are highly likely to seek and find their calories elsewhere.

4). So-called junk food is perfectly nutritious. A big Mac meal comprises meat, bread, salad and potatoes -- which is a mainstream Western diet. If that is bad then we are all in big trouble.

5). Food warriors demonize salt and fat. But we need a daily salt intake to counter salt-loss through perspiration and the research shows that people on salt-restricted diets die SOONER. And Eskimos eat huge amounts of fat with no apparent ill-effects. And the average home-cooked roast dinner has LOTS of fat. Will we ban roast dinners?

6). The foods restricted are often no more calorific than those permitted -- such as milk and fruit-juice drinks.

7). Tendency to weight is mostly genetic and is therefore not readily susceptible to voluntary behaviour change.

8). And when are we going to ban cheese? Cheese is a concentrated calorie bomb and has lots of that wicked animal fat in it too. Wouldn't we all be better off without it? And what about butter and margarine? They are just about pure fat. Surely they should be treated as contraband in kids' lunchboxes! [/sarcasm].

9). And how odd it is that we never hear of the huge American study which showed that women who eat lots of veggies have an INCREASED risk of stomach cancer? So the official recommendation to eat five lots of veggies every day might just be creating lots of cancer for the future! It's as plausible (i.e. not very) as all the other dietary "wisdom" we read about fat etc.

10). And will "this generation of Western children be the first in history to lead shorter lives than their parents did"? This is another anti-fat scare that emanates from a much-cited editorial in a prominent medical journal that said so. Yet this editorial offered no statistical basis for its opinion -- an opinion that flies directly in the face of the available evidence.

Even statistical correlations far stronger than anything found in medical research may disappear if more data is used. A remarkable example from Sociology:

"The modern literature on hate crimes began with a remarkable 1933 book by Arthur Raper titled The Tragedy of Lynching. Raper assembled data on the number of lynchings each year in the South and on the price of an acre's yield of cotton. He calculated the correlation coefficient between the two series at -0.532. In other words, when the economy was doing well, the number of lynchings was lower.... In 2001, Donald Green, Laurence McFalls, and Jennifer Smith published a paper that demolished the alleged connection between economic conditions and lynchings in Raper's data. Raper had the misfortune of stopping his analysis in 1929. After the Great Depression hit, the price of cotton plummeted and economic conditions deteriorated, yet lynchings continued to fall. The correlation disappeared altogether when more years of data were added."

So we must be sure to base our conclusions on ALL the data. But in medical research, data selectivity and the "overlooking" of discordant research findings is epidemic.

*********************

Seven health myths revealed

Reading in dim light won't damage your eyes, you don't need eight glasses of water a day to stay healthy and shaving your legs won't make the hair grow back faster. These well-worn theories are among seven "medical myths" exposed in a paper published Friday in the British Medical Journal, which traditionally carries light-hearted features in its Christmas edition. Two US researchers took seven common beliefs and searched the archives for evidence to support them.

Despite frequent mentions in the popular press of the need to drink eight glasses of water, they found no scientific basis for the claim. The complete lack of evidence has been recorded in a study published the American Journal of Psychology, they said. The other six "myths" are:

* Reading in dim light ruins your eyesight. The majority of eye experts believe it is unlikely to do any permanent damage, but it may make you squint, blink more and have trouble focusing, the researchers said.

* Shaving makes hair grow back faster or coarser. It has no effect on the thickness or rate of hair regrowth, studies say. But stubble lacks the finer taper of unshaven hair, giving the impression of coarseness.

* Eating turkey makes you drowsy. It does contain an amino acid called tryptophan that is involved in sleep and mood control. But turkey has no more of the acid than chicken or minced beef. Eating lots of food and drink at Christmas is probably the real cause of sleepiness.

* We use only 10 per cent of our brains. This myth arose as early as 1907 but imaging shows no area of the brain is silent or completely inactive.

* Hair and fingernails continue to grow after death. This idea may stem from ghoulish novels. The researchers said the skin dries out and retracts after death, giving the appearance of longer hair or nails.

* Mobile phones are dangerous in hospitals. Despite widespread concerns, studies have found minimal interference with medical equipment.

The research was conducted by Aaron Carroll, an assistant professor of pediatrics at the Regenstrief Institute, Indianapolis, and Rachel Vreeman, fellow in children's health services research at Indiana University School of Medicine.

Source






The chocolate merry-go-round

Good for you, bad for you, good for you ....

For those of you tucking into dark chocolate this Christmas using the excuse it is good for you, think again. A top medical journal said any health claims about plain chocolate may be misleading. Plain chocolate is naturally rich in flavanols, plant chemicals that are believed to protect the heart. But an editorial in the Lancet points out that many manufacturers remove flavanols because of their bitter taste. Instead, many products may just be abundant in fat and sugar - both of which are harmful to the heart and arteries, the journal reported.

Previous studies have suggested that plain chocolate can help protect the heart, lower blood pressure and aid tiredness. But the Lancet said: "Dark chocolate can be deceptive. "When chocolate manufacturers make confectionery, the natural cocoa solids can be darkened and the flavanols, which are bitter, removed, so even a dark-looking chocolate can have no flavanol. "Consumers are also kept in the dark about the flavanol content of chocolate because manufacturers rarely label their products with this information."

And the journal also pointed out that even with flavanols present, chocolate-lovers should be mindful of the other contents. "The devil in the dark chocolate is the fat, sugar and calories it also contains. "To gain any health benefit, those who eat a moderate amount of flavanol-rich dark chocolate will have to balance the calories by reducing their intake of other foods - a tricky job for even the most ardent calorie counter.

"So, with the holiday season upon us, it might be worth getting familiar with the calories in a bar of dark chocolate versus a mince pie and having a calculator at hand."

Source

****************

Just some problems with the "Obesity" war:

1). It tries to impose behavior change on everybody -- when most of those targeted are not obese and hence have no reason to change their behaviour. It is a form of punishing the innocent and the guilty alike. (It is also typical of Leftist thinking: Scorning the individual and capable of dealing with large groups only).

2). The longevity research all leads to the conclusion that it is people of MIDDLING weight who live longest -- not slim people. So the "epidemic" of obesity is in fact largely an "epidemic" of living longer.

3). It is total calorie intake that makes you fat -- not where you get your calories. Policies that attack only the source of the calories (e.g. "junk food") without addressing total calorie intake are hence pissing into the wind. People involuntarily deprived of their preferred calorie intake from one source are highly likely to seek and find their calories elsewhere.

4). So-called junk food is perfectly nutritious. A big Mac meal comprises meat, bread, salad and potatoes -- which is a mainstream Western diet. If that is bad then we are all in big trouble.

5). Food warriors demonize salt and fat. But we need a daily salt intake to counter salt-loss through perspiration and the research shows that people on salt-restricted diets die SOONER. And Eskimos eat huge amounts of fat with no apparent ill-effects. And the average home-cooked roast dinner has LOTS of fat. Will we ban roast dinners?

6). The foods restricted are often no more calorific than those permitted -- such as milk and fruit-juice drinks.

7). Tendency to weight is mostly genetic and is therefore not readily susceptible to voluntary behaviour change.

8). And when are we going to ban cheese? Cheese is a concentrated calorie bomb and has lots of that wicked animal fat in it too. Wouldn't we all be better off without it? And what about butter and margarine? They are just about pure fat. Surely they should be treated as contraband in kids' lunchboxes! [/sarcasm].

9). And how odd it is that we never hear of the huge American study which showed that women who eat lots of veggies have an INCREASED risk of stomach cancer? So the official recommendation to eat five lots of veggies every day might just be creating lots of cancer for the future! It's as plausible (i.e. not very) as all the other dietary "wisdom" we read about fat etc.

10). And will "this generation of Western children be the first in history to lead shorter lives than their parents did"? This is another anti-fat scare that emanates from a much-cited editorial in a prominent medical journal that said so. Yet this editorial offered no statistical basis for its opinion -- an opinion that flies directly in the face of the available evidence.

Even statistical correlations far stronger than anything found in medical research may disappear if more data is used. A remarkable example from Sociology:

"The modern literature on hate crimes began with a remarkable 1933 book by Arthur Raper titled The Tragedy of Lynching. Raper assembled data on the number of lynchings each year in the South and on the price of an acre's yield of cotton. He calculated the correlation coefficient between the two series at -0.532. In other words, when the economy was doing well, the number of lynchings was lower.... In 2001, Donald Green, Laurence McFalls, and Jennifer Smith published a paper that demolished the alleged connection between economic conditions and lynchings in Raper's data. Raper had the misfortune of stopping his analysis in 1929. After the Great Depression hit, the price of cotton plummeted and economic conditions deteriorated, yet lynchings continued to fall. The correlation disappeared altogether when more years of data were added."

So we must be sure to base our conclusions on ALL the data. But in medical research, data selectivity and the "overlooking" of discordant research findings is epidemic.

*********************

Beauty and intelligence are linked. Both reflect general biological fitness

One of the most detailed studies on the link between beauty and intelligence was done by Mark Prokosch, Ronald Yeo and Geoffrey Miller, who also work at the University of New Mexico. These three researchers correlated people's bodily symmetry with their performance on intelligence tests. Such tests come in many varieties, of course, and have a controversial background. But most workers in the field agree that there is a quality, normally referred to as "general intelligence", or "g", that such tests can measure objectively along with specific abilities in such areas as spatial awareness and language. Dr Miller and his colleagues found that the more a test was designed to measure g, the more the results were correlated with bodily symmetry-particularly in the bottom half of the beauty-ugliness spectrum.

Faces, too, seem to carry information on intelligence. A few years ago, two of the world's face experts, Leslie Zebrowitz, of Brandeis University in Massachusetts, and Gillian Rhodes, of the University of Western Australia, got together to review the literature and conduct some fresh experiments. They found nine past studies (seven of them conducted before the second world war, an indication of how old interest in this subject is), and subjected them to what is known as a meta-analysis.

The studies in question had all used more or less the same methodology, namely photograph people and ask them to do IQ tests, then show the photographs to other people and ask the second lot to rank the intelligence of the first lot. The results suggested that people get such judgments right-by no means all the time, but often enough to be significant. The two researchers and their colleagues then carried out their own experiment, with the added twist of dividing their subjects up by age.

The results of that were rather surprising. They found that the faces of children and adults of middling years did seem to give away intelligence, while those of teenagers and the elderly did not. That is surprising because face-reading of this sort must surely be important in mate selection, and the teenage years are the time when such selection is likely to be at its most intense-though, conversely, they are also the time when evolution will be working hardest to cover up any deficiencies, and the hormone-driven changes taking place during puberty might provide the material needed to do that. Nevertheless, the accumulating evidence suggests that physical characteristics do give clues about intelligence, that such clues are picked up by other people, and that these clues are also associated with beauty. And other work also suggests that this really does matter.

One of the leading students of beauty and success is Daniel Hamermesh of the University of Texas. Dr Hamermesh is an economist rather than a biologist, and thus brings a somewhat different perspective to the field. He has collected evidence from more than one continent that beauty really is associated with success-at least, with financial success. He has also shown that, if all else is equal, it might be a perfectly legitimate business strategy to hire the more beautiful candidate.

Just over a decade ago Dr Hamermesh presided over a series of surveys in the United States and Canada which showed that when all other things are taken into account, ugly people earn less than average incomes, while beautiful people earn more than the average. The ugliness "penalty" for men was -9% while the beauty premium was +5%. For women, perhaps surprisingly considering popular prejudices about the sexes, the effect was less: the ugliness penalty was -6% while the beauty premium was +4%.

The difference also applies within professions. Dr Hamermesh looked at the careers of members of a particular (though discreetly anonymous) American law school. He found that those rated attractive on the basis of their graduation photographs went on to earn higher salaries than their less well-favoured colleagues. Moreover, lawyers in private practice tended to be better looking than those working in government departments. [Heh!]

More here




New hope from Britain in battle against Clostridium difficile

A vaccine that operates on the same principle as the jab for diphtheria and tetanus could be used to stamp out cases of the virulent hospital superbug Clostridium difficile, researchers say. Scientists will start recruiting patients next year for clinical trials of the vaccine, which has the potential to prevent thousands of deaths in British hospitals each year.

The vaccine, given to healthy patients last year to check its safety, works by using a small quantity of formaldehyde to neutralise toxins emitted by the bacteria. In laboratory trials and tests on at least three patients with chronic C. difficile infections, it rendered these toxins harmless, helping the immune system to fight off illness naturally. A jab against C. difficilecould be provided to at-risk groups within eight years, the researchers suggest.

C. difficile is the most common form of hospital-acquired infection and diarrhoea in the Western world. It contributed to the deaths of nearly 4,000 people last year. Cases of the superbug, which is harder to control than MRSA, increased by 8 per cent last year compared with 2005.

Acambis, the company developing the vaccine, said that it was negotiating with the Department of Health and the Health Protection Agency on whether British patients could take part in the next stage of the trials. The company, based in Cambridge, East Anglia, and Cambridge, Massachusetts, said that it had identified a number of vaccine formulations and planned to begin the second phase of trials towards the end of next year.

The bacterium occurs naturally in the intestines of 3 per cent of healthy adults and two thirds of infants, where it rarely causes problems. However, it can cause illness - from mild to severe diarrhoea, or in some cases severe inflammation of the bowel - when its growth is unchecked. Treatment with antibiotics can disturb the balance of "normal" bacteria in the gut, allowing C. difficile to thrive.

Michael Watson, the executive vice-president for research and development at Acambis, said: "Formaldehyde may be best known as the pickling ingredient for Damien Hirst's shark, but it's also a key ingredient in vaccines against diphtheria, tetanus and whooping cough. "In a typical C. difficile infection the toxins break apart and irritate the lining of the bowel. Our vaccine is designed to prevent this and render the toxins harmless, so they can be destroyed by the immune system."

Most people can recover from an infection naturally but patients whose immune reaction is weakened by age or illness have trouble fighting off the bug. Infections can be treated with antibiotics but an estimated 20-30 per cent of patients suffer a relapse.

The vaccine could provide a longer-term solution to the problem, and counter the emergence of drug-resistant strains, Dr Watson said. "We estimate that between 2010 and 2015, patients could start seeing the benefits," he added. The NHS is also using technology invented to protect Britain against biological weapons to fight superbugs. Air disinfection units, which kill up to 98.5 per cent of germs in the air, including drug-resistant strains of C. difficile, E. coli and MRSA, have been approved for use in hospitals after tests at Porton Down, the Government's bio-warfare research centre in Wiltshire.

Maidstone and Tunbridge Wells hospitals trust in Kent, where at least 90 patients died as a result of C. difficile infections, will be the first to use the technology.

Source

****************

Just some problems with the "Obesity" war:

1). It tries to impose behavior change on everybody -- when most of those targeted are not obese and hence have no reason to change their behaviour. It is a form of punishing the innocent and the guilty alike. (It is also typical of Leftist thinking: Scorning the individual and capable of dealing with large groups only).

2). The longevity research all leads to the conclusion that it is people of MIDDLING weight who live longest -- not slim people. So the "epidemic" of obesity is in fact largely an "epidemic" of living longer.

3). It is total calorie intake that makes you fat -- not where you get your calories. Policies that attack only the source of the calories (e.g. "junk food") without addressing total calorie intake are hence pissing into the wind. People involuntarily deprived of their preferred calorie intake from one source are highly likely to seek and find their calories elsewhere.

4). So-called junk food is perfectly nutritious. A big Mac meal comprises meat, bread, salad and potatoes -- which is a mainstream Western diet. If that is bad then we are all in big trouble.

5). Food warriors demonize salt and fat. But we need a daily salt intake to counter salt-loss through perspiration and the research shows that people on salt-restricted diets die SOONER. And Eskimos eat huge amounts of fat with no apparent ill-effects. And the average home-cooked roast dinner has LOTS of fat. Will we ban roast dinners?

6). The foods restricted are often no more calorific than those permitted -- such as milk and fruit-juice drinks.

7). Tendency to weight is mostly genetic and is therefore not readily susceptible to voluntary behaviour change.

8). And when are we going to ban cheese? Cheese is a concentrated calorie bomb and has lots of that wicked animal fat in it too. Wouldn't we all be better off without it? And what about butter and margarine? They are just about pure fat. Surely they should be treated as contraband in kids' lunchboxes! [/sarcasm].

9). And how odd it is that we never hear of the huge American study which showed that women who eat lots of veggies have an INCREASED risk of stomach cancer? So the official recommendation to eat five lots of veggies every day might just be creating lots of cancer for the future! It's as plausible (i.e. not very) as all the other dietary "wisdom" we read about fat etc.

10). And will "this generation of Western children be the first in history to lead shorter lives than their parents did"? This is another anti-fat scare that emanates from a much-cited editorial in a prominent medical journal that said so. Yet this editorial offered no statistical basis for its opinion -- an opinion that flies directly in the face of the available evidence.

Even statistical correlations far stronger than anything found in medical research may disappear if more data is used. A remarkable example from Sociology:

"The modern literature on hate crimes began with a remarkable 1933 book by Arthur Raper titled The Tragedy of Lynching. Raper assembled data on the number of lynchings each year in the South and on the price of an acre's yield of cotton. He calculated the correlation coefficient between the two series at -0.532. In other words, when the economy was doing well, the number of lynchings was lower.... In 2001, Donald Green, Laurence McFalls, and Jennifer Smith published a paper that demolished the alleged connection between economic conditions and lynchings in Raper's data. Raper had the misfortune of stopping his analysis in 1929. After the Great Depression hit, the price of cotton plummeted and economic conditions deteriorated, yet lynchings continued to fall. The correlation disappeared altogether when more years of data were added."

So we must be sure to base our conclusions on ALL the data. But in medical research, data selectivity and the "overlooking" of discordant research findings is epidemic.

*********************

DOING NOTHING REDUCES YOUR BLOOD PRESSURE SLIGHTLY

Not exactly a great surprise but that seems to be the conclusion below. Popular summary followed by journal abstract

MEDITATION may not only relax the mind, it could also reduce high blood pressure. In Current Hypertension Reports this week, researchers have combined the results of 23 published studies on stress reduction programs and high blood pressure. In each of the studies, participants were randomly assigned to either a stress reduction technique or placebo-type control for at least eight weeks. The transcendental meditation technique, which involves sitting comfortably with your eyes closed for 15 to 20 minutes twice a day, significantly reduced high blood pressure. This effect was not seen with any of the other forms of relaxation tested, including other types of meditation and stress management. On average, transcendental meditation reduced systolic blood pressure (the peak pressure in the arteries, reported first in a blood pressure reading) by 5.0 points and diastolic blood pressure (the lowest pressure in the arteries, reported second) by 2.8 points compared to no treatment. This form of meditation could be used alongside prescribed medications to lower blood pressure, say the authors.

Source

Stress Reduction Programs in Patients with Elevated Blood Pressure: A Systematic Review and Meta-analysis

By Maxwell V. Rainforth et al.

Substantial evidence indicates that psychosocial stress contributes to hypertension and cardiovascular disease (CVD). Previous meta-analyses of stress reduction and high blood pressure (BP) were outdated and/or methodologically limited. Therefore, we conducted an updated systematic review of the published literature and identified 107 studies on stress reduction and BP. Seventeen trials with 23 treatment comparisons and 960 participants with elevated BP met criteria for well-designed randomized controlled trials and were replicated within intervention categories. Meta-analysis was used to calculate BP changes for biofeedback, -0.8/-2.0 mm Hg (P = NS); relaxation-assisted biofeedback, +4.3/+2.4 mm Hg (P = NS); progressive muscle relaxation, -1.9/-1.4 mm Hg (P = NS); stress management training, -2.3/-1.3 mm (P = NS); and the Transcendental Meditation program, -5.0/-2.8 mm Hg (P = 0.002/0.02). Available evidence indicates that among stress reduction approaches, the Transcendental Meditation program is associated with significant reductions in BP. Related data suggest improvements in other CVD risk factors and clinical outcomes.

Current Hypertension Reports 2007, 9:520-528




IGNORING THE OBVIOUS

If you had a close relative who had Parkinsons (the shakes), wouldn't it tend to make you depressed and anxious? If I had such a relative the fear of getting it myself would certainly freak me. But the geniuses below cannot apparently see that. They think there is some biological connection between Parkinsons and depression. Note also that there seems to have been no controls for observer bias. Raters should have been given histories of both relatives and non-relatives without being told which was which

Increased Risk of Depressive and Anxiety Disorders in Relatives of Patients With Parkinson Disease

By Gennarina Arabia et al.

Context: Relatives of patients with Parkinson disease (PD) have an increased risk of PD and other neurologic disorders; however, their risk of psychiatric disorders remains uncertain.

Objective: To study the risk of depressive disorders and anxiety disorders among first-degree relatives of patients with PD compared with first-degree relatives of controls.

Design, Setting, and Participants: In a population-based, historical cohort study, we included 1000 first-degree relatives of 162 patients with PD and 850 first-degree relatives of 147 controls. Both patients with PD and controls were representative of the population of Olmsted County, Minnesota.

Main Outcome Measures: Documentation of psychiatric disorders was obtained for each relative separately through a combination of telephone interviews with the relatives (or their proxies) and review of their medical records from a records-linkage system (family study method). Psychiatric disorders were defined using clinical criteria from the DSM-IV or routine diagnoses.

Results: We found an increased risk of several psychiatric disorders in first-degree relatives of patients with PD compared with first-degree relatives of controls (hazard ratio [HR], 1.54; 95% confidence interval [CI], 1.21-1.95; P <.001). In particular, we found an increased risk of depressive disorders (HR, 1.45; 95% CI, 1.11-1.89; P = .006) and anxiety disorders (HR, 1.55; 95% CI, 1.05-2.28; P = .03). The results were consistent in analyses that adjusted for type of interview, excluded relatives who developed parkinsonism, or excluded relatives who developed both a depressive disorder and an anxiety disorder.

Conclusion: These findings suggest that depressive disorders and anxiety disorders may share familial susceptibility factors with PD.

Arch Gen Psychiatry. 2007;64(12):1385-1392

**********************

Just some problems with the "Obesity" war:

1). It tries to impose behavior change on everybody -- when most of those targeted are not obese and hence have no reason to change their behaviour. It is a form of punishing the innocent and the guilty alike. (It is also typical of Leftist thinking: Scorning the individual and capable of dealing with large groups only).

2). The longevity research all leads to the conclusion that it is people of MIDDLING weight who live longest -- not slim people. So the "epidemic" of obesity is in fact largely an "epidemic" of living longer.

3). It is total calorie intake that makes you fat -- not where you get your calories. Policies that attack only the source of the calories (e.g. "junk food") without addressing total calorie intake are hence pissing into the wind. People involuntarily deprived of their preferred calorie intake from one source are highly likely to seek and find their calories elsewhere.

4). So-called junk food is perfectly nutritious. A big Mac meal comprises meat, bread, salad and potatoes -- which is a mainstream Western diet. If that is bad then we are all in big trouble.

5). Food warriors demonize salt and fat. But we need a daily salt intake to counter salt-loss through perspiration and the research shows that people on salt-restricted diets die SOONER. And Eskimos eat huge amounts of fat with no apparent ill-effects. And the average home-cooked roast dinner has LOTS of fat. Will we ban roast dinners?

6). The foods restricted are often no more calorific than those permitted -- such as milk and fruit-juice drinks.

7). Tendency to weight is mostly genetic and is therefore not readily susceptible to voluntary behaviour change.

8). And when are we going to ban cheese? Cheese is a concentrated calorie bomb and has lots of that wicked animal fat in it too. Wouldn't we all be better off without it? And what about butter and margarine? They are just about pure fat. Surely they should be treated as contraband in kids' lunchboxes! [/sarcasm].

9). And how odd it is that we never hear of the huge American study which showed that women who eat lots of veggies have an INCREASED risk of stomach cancer? So the official recommendation to eat five lots of veggies every day might just be creating lots of cancer for the future! It's as plausible (i.e. not very) as all the other dietary "wisdom" we read about fat etc.

10). And will "this generation of Western children be the first in history to lead shorter lives than their parents did"? This is another anti-fat scare that emanates from a much-cited editorial in a prominent medical journal that said so. Yet this editorial offered no statistical basis for its opinion -- an opinion that flies directly in the face of the available evidence.

Even statistical correlations far stronger than anything found in medical research may disappear if more data is used. A remarkable example from Sociology:

"The modern literature on hate crimes began with a remarkable 1933 book by Arthur Raper titled The Tragedy of Lynching. Raper assembled data on the number of lynchings each year in the South and on the price of an acre's yield of cotton. He calculated the correlation coefficient between the two series at -0.532. In other words, when the economy was doing well, the number of lynchings was lower.... In 2001, Donald Green, Laurence McFalls, and Jennifer Smith published a paper that demolished the alleged connection between economic conditions and lynchings in Raper's data. Raper had the misfortune of stopping his analysis in 1929. After the Great Depression hit, the price of cotton plummeted and economic conditions deteriorated, yet lynchings continued to fall. The correlation disappeared altogether when more years of data were added."

So we must be sure to base our conclusions on ALL the data. But in medical research, data selectivity and the "overlooking" of discordant research findings is epidemic.

*********************

MORE ON "EVIDENCE-BASED MEDICINE"

Following is an email I received from a specialist anesthetist

EBM has become a "buzzword" of the Health Care Administration, with several "agendas":

1. Somehow bureaucrats are playing "catch up", like THEY invented EBM to "purify" those dumb doctors. Much is a ploy to save money - somewhat like Leftists NEVER being satisfied with Bush's performance in war and economics, there is NEVER enough medical evidence to "prove beyond a doubt" that some treatment is valid. This saves money for the insurance company. Since NO therapy can be "absolutely proven", insurers LOVE EBM.

2. There is ANOTHER agenda - to take decision making away from the physician by publishing "guidelines" that any aide or nurse can perform - by reading the manual. This locks doctors out of the loop.

3. Much of this EBM in recent years comes from primary care - presented as NEW because it is NEW TO THEM. For many years, they have practiced based on "my experience", more often flawed than EBM. They think that application of science to medicine is something new.

In truth, anesthesiologists have known about this stuff for generations. It was an anesthesiologist (Virginia Apgar) who developed a scoring system for evaluation of newborns in the 50.s. This numerical score was the FIRST score for such, which in the past was simply descriptive. Since the 1930's, science has been a core value of anesthesiologists. We laugh at such arrogance among the primary care and health care bureaucracies.







IS TESTOSTERONE A FOUNTAIN OF YOUTH?

The study below showed that giving testosterone patches to old guys with low testosterone levels produced slimmer tummies and more muscle. What the inevitable downside might be is not yet known. Shorter lifespan is a possibility. And whether it helps normal men of that or other ages is not shown

Testosterone Therapy Prevents Gain in Visceral Adipose Tissue and Loss of Skeletal Muscle in Non-obese Aging Men

By C. A. Allan et al.

Background: Trials of testosterone therapy in aging men have demonstrated increases in fat free mass and skeletal muscle, and decreases in fat mass, but have not reported the impact of baseline body composition.

Objective: To determine the effect, in non-obese aging men with symptoms of androgen deficiency and low-normal serum testosterone levels, of testosterone therapy on total and regional body composition, and hormonal and metabolic indices.

Methods: 60 healthy but symptomatic, non-obese men aged ~ 55 years with TT levels <15nM were randomized to transdermal testosterone patches or placebo for 12 months. Body composition, by DEXA (fat mass, fat free mass, skeletal muscle) and MRI (abdominal subcutaneous and visceral adipose tissue, thigh skeletal muscle and intermuscular fat) and hormonal and metabolic parameters were measured at Weeks 0 and 52.

Results: Serum TT increased by 30% (P=0.01) LH decreased by 50% (P<0.001). Relative to placebo, total body fat free mass (P=0.03) and skeletal muscle (P=0.008) were increased and thigh skeletal muscle loss was prevented (P=0.045) with testosterone therapy while visceral fat accumulation decreased (P=0.001) without change in total body or abdominal subcutaneous fat mass; change in visceral fat was correlated with change in TT levels (r2=0.36; P=0.014). There was a trend to increasing total and LDL cholesterol with placebo.

Conclusion: Testosterone therapy, relative to placebo, selectively lessened visceral fat accumulation without change in total body fat mass, and increased total body fat free mass and total body and thigh skeletal muscle mass. Further studies are needed to determine the impact of these body compositional changes on markers of metabolic and cardiovascular risk.

Journal of Clinical Endocrinology & Metabolism, October 16, 2007

****************

Just some problems with the "Obesity" war:

1). It tries to impose behavior change on everybody -- when most of those targeted are not obese and hence have no reason to change their behaviour. It is a form of punishing the innocent and the guilty alike. (It is also typical of Leftist thinking: Scorning the individual and capable of dealing with large groups only).

2). The longevity research all leads to the conclusion that it is people of MIDDLING weight who live longest -- not slim people. So the "epidemic" of obesity is in fact largely an "epidemic" of living longer.

3). It is total calorie intake that makes you fat -- not where you get your calories. Policies that attack only the source of the calories (e.g. "junk food") without addressing total calorie intake are hence pissing into the wind. People involuntarily deprived of their preferred calorie intake from one source are highly likely to seek and find their calories elsewhere.

4). So-called junk food is perfectly nutritious. A big Mac meal comprises meat, bread, salad and potatoes -- which is a mainstream Western diet. If that is bad then we are all in big trouble.

5). Food warriors demonize salt and fat. But we need a daily salt intake to counter salt-loss through perspiration and the research shows that people on salt-restricted diets die SOONER. And Eskimos eat huge amounts of fat with no apparent ill-effects. And the average home-cooked roast dinner has LOTS of fat. Will we ban roast dinners?

6). The foods restricted are often no more calorific than those permitted -- such as milk and fruit-juice drinks.

7). Tendency to weight is mostly genetic and is therefore not readily susceptible to voluntary behaviour change.

8). And when are we going to ban cheese? Cheese is a concentrated calorie bomb and has lots of that wicked animal fat in it too. Wouldn't we all be better off without it? And what about butter and margarine? They are just about pure fat. Surely they should be treated as contraband in kids' lunchboxes! [/sarcasm].

9). And how odd it is that we never hear of the huge American study which showed that women who eat lots of veggies have an INCREASED risk of stomach cancer? So the official recommendation to eat five lots of veggies every day might just be creating lots of cancer for the future! It's as plausible (i.e. not very) as all the other dietary "wisdom" we read about fat etc.

10). And will "this generation of Western children be the first in history to lead shorter lives than their parents did"? This is another anti-fat scare that emanates from a much-cited editorial in a prominent medical journal that said so. Yet this editorial offered no statistical basis for its opinion -- an opinion that flies directly in the face of the available evidence.

Even statistical correlations far stronger than anything found in medical research may disappear if more data is used. A remarkable example from Sociology:

"The modern literature on hate crimes began with a remarkable 1933 book by Arthur Raper titled The Tragedy of Lynching. Raper assembled data on the number of lynchings each year in the South and on the price of an acre's yield of cotton. He calculated the correlation coefficient between the two series at -0.532. In other words, when the economy was doing well, the number of lynchings was lower.... In 2001, Donald Green, Laurence McFalls, and Jennifer Smith published a paper that demolished the alleged connection between economic conditions and lynchings in Raper's data. Raper had the misfortune of stopping his analysis in 1929. After the Great Depression hit, the price of cotton plummeted and economic conditions deteriorated, yet lynchings continued to fall. The correlation disappeared altogether when more years of data were added."

So we must be sure to base our conclusions on ALL the data. But in medical research, data selectivity and the "overlooking" of discordant research findings is epidemic.

*********************

Patients beating the regulators

Lots of people die while regulators take years to evaluate new treatments so it is good that there is a loophole for those who are prepared to take a risk

Australians with type 2 diabetes are signing up for a costly, unproven stem cell "cure" at a South American clinic. The San Nicolas Clinic says 89per cent of its patients are insulin and medication-free 90 days after being injected with their own stem cells. The treatment costs $US16,000. Some patients who have undergone the same stem-cell therapy for heart disease - which is illegal in all Western countries - say it has given them "a new lease on life". But the world's leading stem-cell scientists warn that patients desperate for a miracle cure are putting themselves at grave risk by undergoing a treatment yet to be fully tested in humans.

The San Nicolas Clinic is bank-rolled by a US energy corporation and is part of the International Clinics of Regenerative Medicine. ICORM director Mike Bartlett said more than 300 patients had been successfully treated for heart disease, diabetes, emphysema and Parkinson's disease at its hospitals in South America and Asia. Mr Bartlett spent last week in Sydney meeting diabetes specialists and cardiologists to encourage them to refer their end-stage patients. To date, 31 Australians with type2 diabetes and seven with heart disease had indicated a wish to travel to Argentina as soon as possible, and a further 208 had made inquiries, he said.

Dr Ross Walker, a Sydney Adventist Hospital cardiologist and author of the bestselling book The Cell Factor, said he would travel to the San Nicolas Clinic early next year to assess the claims for himself. "I believe it is the next big thing in medicine but I want to see solid scientific evidence that it doesn't do any harm before recommending it for the wider population," he said.

Under the patented process, 250millilitres of a patient's blood is manipulated to yield millions of therapeutic stem cells. The cells are then injected into the diseased organ or tissue. Patients are usually sent home within two days. Numerous patients have testified to the "miraculous" effects of the treatment, which uses adult stem cells, not the more ethically-questionable embryonic stem cells. Keith Fanning said the $70,000 he spent flying his dying father, Mick, 75, to Bangkok for stem-cell therapy was "the best $70,000 I ever spent". Oxygen-dependent and barely able to walk before the procedure in July, Mr Fanning's ejection fraction (EF) - the measurement of the capacity at which the heart is pumping - increased so much that he can now breathe, talk and eat on his own. His insulin dependency is also down and his violent shaking from Parkinson's has virtually disappeared. "I'm the ultimate sceptic and it's the closest thing I've seen to a miracle," he said from his Queensland home.

In October, Lynley White, from Melbourne, spent $45,000 to have 30 stem-cell injections in her heart after traditional drug therapy failed to improve her cardiomyopathy. "My doctors laughed at me and said I had rocks in my head but so far so good. I'm feeling more and more energetic," she said. At 62, she was unlikely to receive the heart transplant she needed to keep going. Of the 120 people who have tried the treatment at Bangkok Heart Hospital, four have died. But Mrs White said her only fear was she would not survive the anaesthetic. "My ejection fraction was getting lower and lower - it got down to 12 when it should be 55 plus - and I thought 'I've got to help myself'," she said. Immediately after treatment her EF rating was up by 64 per cent.

Dr Teija Peura, director of human embryonic stem cell laboratories at the Australian Stem Cell Centre, said: "It's understandable that patients who are desperate can't wait for treatment to go through the approval process but it's dangerous because these countries are giving treatment which they don't know how or why [it] works." The International Society for Stem Cell Research said the only stem cell-based therapy with clearly proven efficacy was bone marrow transplantation for blood disorders and leukaemia.

Source





The British scene: Don't drink if you want to be merry

With undercover cops spying on pub staff, and everyone else conforming to official wisdom on 'binge-drinking', Xmas boozing might be a rather flat affair.

When you're sipping a festive pint in your cosy local this Christmas, beware the figure lurking behind you, strangely interested in your trips to the bar. In Blackpool, England, recently, police piloted a scheme where undercover officers spied on patrons and bar staff. The underwhelming result of this dragnet was that two bar staff were fined for serving drunk customers. Now it looks like this scheme could be heading to a boozer near you (1). But it's not just the forces of law and order watching our behaviour that we should be concerned about - it's the little puritan voice inside our heads, as scripted by health campaigners and moral guardians.

The plainclothes surveillance scheme in Blackpool is one of a recent barrage of initiatives and commentary aimed at Britain's apparently frenzied and deadly alcohol consumption. The campaign on drink driving isn't just for Christmas anymore, it's for life. Other government-funded adverts remind us that while we may feel superhuman after a drink or two, that's precisely when we're more likely to have an accident. Then there's the constant advice to count the number of units you consume (as if you could count after a session).

The media draw daily on Dantesque visions of our streets as `the playgrounds of puking post-adolescents' (2) where `weekend droves pile into chain pubs and the police have been known to set up mobile holding rooms' (3). While `confessions of a middle-class binge drinker' columns sniggered at recent panics about `respectable' home drinking, the drive for behaviour modification has continued apace. Even the homely Campaign for Real Ale (Camra) now defines pubs as `the proper place to enjoy a drink in a responsible and regulated atmosphere' (4).

The attack on our drinking habits is part of a wider process in which the political class and lifestyle authoritarians, lacking any grander vision of the world, turn the banal facts of existence - like the things we consume for sustenance and pleasure - into morally charged issues because they have little to offer us in any other sphere. And whether they are haranguing us about public behaviour or private habits, the space they really want to colonise is inside our heads: our guilty consciences.

This potent cocktail of conformity is two parts misanthropy to one part health neurosis. When we swallow this mix - apologising for that next glass, fretting about another cigarette or worrying about the letch at the Christmas party - we are doing the puritans' work for them. As Dolan Cummings argued in a recent essay, when smokers say they welcome the ban on public smoking because it will help them quit, they `express a peculiar sort of resolution: one which they claim to be incapable of exercising without external compulsion. By banning smoking in pubs, we collectively save ourselves from temptation.' (5)

An Australian business venture provides a startling illustration of this increasing rejection of personal responsibility. In 2004, Virgin Mobile responded to an apparent Aussie epidemic of embarrassing drunken calls to exes and colleagues. Their service allowed customers, before drinking, to dial `333' followed by the number they wanted to avoid `drunk dialling'. For 25 cents, attempts to phone blacklisted numbers initiate a message: `This call cannot be connected; this is for your own good.' Psychologist John McIlroy believed `it could come in handy for Americans who know themselves well enough to not have self-control over their impulses' (6).

This version of the human subject as incapable of personal restraint leads to obsessive use of the term `binge' in alcohol coverage. The hysterical portrayal of bingeing also exposes the root of anti-alcohol culture: a fear of human agency and by implication humanity itself.

Alcohol becomes the locus for behaviour politics because it removes inhibitions, acting as social glue. Drink can make us feel fearless, free or profound. At the right pitch of tipsiness, alcohol exaggerates our great qualities; we're perhaps more animated, articulate or communicative. Whether that's about anything of substance is another matter. Alcohol can also magnify morbidity or aggression, it is true, but current policy is founded on the assumption that these murkier qualities will emerge in the first sip of a pint. The assumption is that everyone needs some kind of rules and regulation because we can all suddenly `get out of hand' (7).

The heightened sense of freedom alcohol provides is precisely why it's troubling - and the pleasure it provides so baffling - to increasing numbers of official killjoys. Current `drink responsibly' public information films betray fears that the demon drink will unleash the violent, vile core lurking beneath the thin veneer of polite social intercourse. The evolution of attitudes to smoking from a private matter to a public scourge reveals how potent the desire to control our conduct has become. Below I have listed what I consider to be key rhetorical stages in the journey from liberty to prohibition - best illustrated by the bans on public smoking but increasingly defining the discussion of alcohol, too:

Availability phase: availability is problematic, with the suggestion that we're bombarded with advertising seducing us to rabidly consume cut-price crates. Youth, it is said, are hit hardest.

Health/crime phase: consumption, we are told, leads to ill-health or criminality. The proper priorities are to extend your life and to relieve your financial burden on the state, showing you're a morally worthy individual by demonstrating health preoccupations. Because disease/crime can result from consumption, such behaviour is therefore inherently bad. Redefining previously acceptable consumption as `abuse' or `addiction' is key.

Anti-social phase: consumption is discussed as anti-social, displaying offensive disregard for sacred environmental and psychological concerns; it pollutes air and relationships. This phase overlaps with the health/crime phase because `the government is redefining "the social" to mean an area where people cause a costly amount of damage (either fiscal or environmental) that the government has to mop up' (8).

Misanthropic momentum phase: warnings are issued that control-measures only go part of the way to addressing much deeper problems that require further bans/legislation/education, particularly surrounding people's ability to parent.

Common sense phase: in the run-up to a ban, and in the period after, the defining outlook is silent compliance. To argue that the ban is an infringement on freedom is to challenge the health position, and is therefore an affront to common sense and `The Science'.

For those who don't believe that restrictions on public intoxication are likely, it should be noted that drunkenness in public is already illegal in many US states. Serving an intoxicated patron has been illegal in Australia since 1998. The increasingly aggressive implementation of intoxication law in these countries serves as sobering examples of how the campaign against drunkenness could play out in Britain.

In Virginia, during Christmas 2003, local police launched a sting on 20 neighbourhood bars and restaurants to `apprehend "drunk" patrons before they try to drive'. Officials said evidence could have been based on `unflicked cigarette ashes, an excessive number of restroom visits, noisy cursing, or a wobbly walk'. Police in Dallas have performed similar sting operations on the publicly legless. In 2006, agents entered 36 bars and arrested 30 people for public intoxication (9). In August 2007, San Diego City Council banned alcohol on all city beaches and parks for a year trial period.

An essay by American sociologist William Sumner, written in 1883, throws light on the deadening logic of behaviour manipulation policy. In the essay, entitled `On the Case of a Certain Man Who Is Never Thought Of', Sumner notes: `The fallacy of all prohibitory, sumptuary, and moral legislation is the same. A and B determine to be teetotallers, which is often a wise determination, and sometimes a necessary one. If A and B are moved by considerations which seem to them good, that is enough. But A and B put their heads together to get a law passed which shall force C to be a teetotaller for the sake of D, who is in danger of drinking too much. There is no pressure on A and B. They are having their own way, and they like it. There is rarely any pressure on D. He does not like it, and evades it. The pressure all comes on C. The question then arises: who is C? He is the man who wants alcoholic liquors for any honest purpose whatsoever, who would use his liberty without abusing it. He is the Forgotten Man again. what each one of us ought to be.' (10)

The public tap on the back from bar-room spies is overtly Orwellian, yet it's the internal spying we really have to watch: measuring yourself against `concerning' statistics; suddenly reassessing intake; seeing others as vulnerable. So, for example, daft drunken antics are now reframed as potentially psychologically damaging. This is why staff Christmas parties were vetoed by nine out of 10 employers last year over fears they could lead to tribunal claims. A survey of 4,915 companies showed most managers fear that employees may behave inappropriately and drink too much alcohol at the office party. The striking majority of respondents (86 per cent) said they'd received complaints from staff due to a Christmas party incident (11).

The new prohibition project - whether it relates to smoking, drinking, or interpersonal office relationships - relies on making us internalise ever-restricted norms of what is `healthy' and `dangerous' activity. We could ignore the momentum of behaviour politics and adopt the state's dim view of us: as forever in need of protection from ourselves and each other. It would be better, however, to forget what our indiscretions might cost the National Health Service and remember the social cost of perceiving everyday freedoms and interactions as little more than potential occasions for harm.

Source

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Just some problems with the "Obesity" war:

1). It tries to impose behavior change on everybody -- when most of those targeted are not obese and hence have no reason to change their behaviour. It is a form of punishing the innocent and the guilty alike. (It is also typical of Leftist thinking: Scorning the individual and capable of dealing with large groups only).

2). The longevity research all leads to the conclusion that it is people of MIDDLING weight who live longest -- not slim people. So the "epidemic" of obesity is in fact largely an "epidemic" of living longer.

3). It is total calorie intake that makes you fat -- not where you get your calories. Policies that attack only the source of the calories (e.g. "junk food") without addressing total calorie intake are hence pissing into the wind. People involuntarily deprived of their preferred calorie intake from one source are highly likely to seek and find their calories elsewhere.

4). So-called junk food is perfectly nutritious. A big Mac meal comprises meat, bread, salad and potatoes -- which is a mainstream Western diet. If that is bad then we are all in big trouble.

5). Food warriors demonize salt and fat. But we need a daily salt intake to counter salt-loss through perspiration and the research shows that people on salt-restricted diets die SOONER. And Eskimos eat huge amounts of fat with no apparent ill-effects. And the average home-cooked roast dinner has LOTS of fat. Will we ban roast dinners?

6). The foods restricted are often no more calorific than those permitted -- such as milk and fruit-juice drinks.

7). Tendency to weight is mostly genetic and is therefore not readily susceptible to voluntary behaviour change.

8). And when are we going to ban cheese? Cheese is a concentrated calorie bomb and has lots of that wicked animal fat in it too. Wouldn't we all be better off without it? And what about butter and margarine? They are just about pure fat. Surely they should be treated as contraband in kids' lunchboxes! [/sarcasm].

9). And how odd it is that we never hear of the huge American study which showed that women who eat lots of veggies have an INCREASED risk of stomach cancer? So the official recommendation to eat five lots of veggies every day might just be creating lots of cancer for the future! It's as plausible (i.e. not very) as all the other dietary "wisdom" we read about fat etc.

10). And will "this generation of Western children be the first in history to lead shorter lives than their parents did"? This is another anti-fat scare that emanates from a much-cited editorial in a prominent medical journal that said so. Yet this editorial offered no statistical basis for its opinion -- an opinion that flies directly in the face of the available evidence.

Even statistical correlations far stronger than anything found in medical research may disappear if more data is used. A remarkable example from Sociology:

"The modern literature on hate crimes began with a remarkable 1933 book by Arthur Raper titled The Tragedy of Lynching. Raper assembled data on the number of lynchings each year in the South and on the price of an acre's yield of cotton. He calculated the correlation coefficient between the two series at -0.532. In other words, when the economy was doing well, the number of lynchings was lower.... In 2001, Donald Green, Laurence McFalls, and Jennifer Smith published a paper that demolished the alleged connection between economic conditions and lynchings in Raper's data. Raper had the misfortune of stopping his analysis in 1929. After the Great Depression hit, the price of cotton plummeted and economic conditions deteriorated, yet lynchings continued to fall. The correlation disappeared altogether when more years of data were added."

So we must be sure to base our conclusions on ALL the data. But in medical research, data selectivity and the "overlooking" of discordant research findings is epidemic.

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