Friday, April 18, 2008

Studies Show It's Often Cheaper To Let People Get Sick

An ounce of prevention may have been worth a pound of cure in households down through the ages, but in the world of health economics the adage, alas, is not true. An ounce of prevention is sometimes worth more than an ounce of cure (although rarely worth 16 times as much, or the equivalent of a pound). Usually, an ounce of prevention is worth considerably less. Often it is worth (to mix measures) only a gram of cure. Or even just a milligram.

This is a seemingly illogical truth. Most of us naturally assume that preventing a disease is cheaper than waiting for the disease to appear and then treating it. That belief is especially dear to politicians, who often view prevention as an underused weapon in the battle against health-care costs. The campaign Web site for Sen. Hillary Clinton (D-N.Y.) notes that her health-care plan is "targeting the drivers of health-care costs, including our back-ended coverage of health care that gives short shrift to prevention." Rival Sen. Barack Obama (D-Ill.) asserts that American families can save up to $2,500 a year each if five cost-containing strategies are implemented, one of which is "improving prevention and management of chronic conditions." (The presumed Republican nominee, Arizona Sen. John McCain, generally has not pushed prevention as a way to control expenses.)

Even when prevention greatly reduces future cases of a particular illness, overall cost to the health-care system typically goes up when lots of disease-preventing strategies are put into practice. This is usually true whether treating the preventable diseases is cheap or expensive. In 1986, a health economist named Louise B. Russell published "Is Prevention Better Than Cure?," in which she concluded that prevention activities tend to cost more than they save. Since the book's appearance, her observation has been borne out by studies of hundreds of interventions -- everything from offering mammograms to all women and prescribing drugs to people with high cholesterol to requiring passenger-side air bags in cars and shortening the response time of ambulances.

On closer look, this isn't so surprising. Nor is it reason for despair. After all, you get something from prevention -- less disease, for starters -- which is worth a lot even if it doesn't come cheap.

There are many reasons prevention usually doesn't save money. Perhaps the most important is that prevention activities target many more people than will ever come down with the disease being prevented. The reason (thankfully) is that people tend to stay healthy for most of their lives, no matter what they do. Take the example of lowering cholesterol to prevent heart attacks.

The vocabulary of cardiac risk uses such terms as "normal," "high" and "very high." But in reality, most people even in the "very high" risk category don't suffer heart attacks over quite long time horizons. Consider a 50-year-old male smoker whose total cholesterol is in the "high" range (over 240); whose HDL, or desirable cholesterol fraction, is "low" (below 40); and who has untreated moderate hypertension. Sounds like a walking time bomb! It turns out his chance of having a heart attack in the next 10 years is only 25 percent. For a woman with the same profile, the chance of having a heart attack is 11 percent. Almost nine out of 10 such people will dodge the bullet by . . . doing nothing.

Preventing those heart attacks is expensive because everyone fitting the risk profile needs to get the intervention. Why? Because there's no way to know in advance who the 1-in-4 unlucky men or 1-in-9 unlucky women are.

If the prevention strategy is taking a statin -- a very effective cholesterol-lowering drug -- it will cost $160,000 for every year of life saved among men with the above-described risk profile. For women, it will be even pricier: $240,000 for every year of life saved, according to a study published in the Annals of Internal Medicine in 2000. (That total bill includes the cost of physician visits and lab tests). It seems like a lot to pay. But who among us would choose 1-in-4 or 1-in-9 odds of having a heart attack if the alternative is to reduce the odds dramatically by taking a pill every day (especially if you don't have to pay for the pill yourself)?

In the answer to that question lies both the appeal of our increasingly prevention-oriented health-care system and the reason why prevention tends to drive costs up over the long run. Prevention can be expensive even when it doesn't involve taking drugs or undergoing procedures. Even giving information can be uneconomical. That's because giving information takes time, and the yield in terms of behavior change that leads to less disease is very low -- as anyone who has been told to eat less and exercise more knows. For example, Australian researchers tried out a program in which general practitioners watched a video and read a booklet about how to help their patients lower their heart attack risk. The patients were then given a series of videos and a self-help booklet on the same topic. How cost-effective is this instruction? When it is provided for women at low risk of heart disease, $9.8 million has to be spent for every year of life saved in the prevention of premature heart attack deaths.

Of course, there are situations in which prevention is the economical choice, even if it still adds to the total spent on health care. Take smoking. Smoking cigarettes is probably the most unhealthful legal thing a person can do. Nevertheless, most lifelong smokers will make it to age 70 without paying the ultimate price. This was borne out in a study published two years ago. Medical researchers in Norway observed the experience of 50,000 Norwegian men and women over a 25-year period. Of the men who smoked more than a pack of cigarettes a day the entire time, 41 percent died between age 40 and 70. Among similarly heavy-smoking women, 26 percent died. (For people who never smoked, the mortality was 14 percent for men and 9 percent for women). Even for heavy smokers, the odds favor survival.

Nevertheless, doing almost anything to help people quit smoking is likely to be a good investment. That's because even though most people get to age 70, lots don't -- but might if they didn't smoke. In just one example of dozens of cost-effectiveness studies examining strategies to reduce smoking deaths, a team of British researchers in 2002 calculated that providing brief counseling, nicotine replacement and the anti-craving drug buproprion to smokers would save one year of life for every $1,300 spent -- an incredible bargain.

There are also some disease-preventing activities that save money, although they are relatively rare. Childhood vaccinations are the classic examples. Many of the infections they protect against -- chickenpox, measles, mumps -- are ones nearly every child would get if not for the shots. Even though few of those cases put children in the hospital or cost much to treat, virtually all that expense (and a few lives) are saved with universal childhood immunization. If vaccines are cheap and easy to administer, the total cost of vaccination is actually less than the cost of treating the cases of illness that would occur in their absence.

Toward the other end of life, providing a single colonoscopy to men 60 to 64 years old also saves money. Even though the procedure costs more than $1,000, it takes such a huge bite out of expensive, painful, life-shortening colon cancer mortality that it costs less to test everybody than to treat the people who would otherwise develop the disease.

"In order to crack this nut [of controlling health-care spending], careful thought and analysis has to go into evaluating what things work, how well things work and how much they cost," said Joshua T. Cohen of the Institute for Clinical Research and Health Policy Studies at Tufts Medical Center in Boston. Similar to the finding that prevention rarely saves money is the calculation that people in good health probably rack up higher lifetime medical costs than their less-healthy brethren. The reason? Healthy people tend to live longer.

The Framingham Heart Study has followed more than 5,000 people in a town outside Boston since 1948. An analysis published in 2003 found that obese women smokers lost 13.3 years of life, and obese men smokers lost 13.7 years, compared with normal-weight nonsmokers. This loss of longevity can make a big economic difference because people who miss old age miss the high medical costs associated with it.

In the journal PLoS Medicine last month, Dutch researchers led by Pieter H.M. van Baal used mathematical modeling to compare the medical expenses (starting at age 20) of healthy people, obese people and non-obese smokers. Up to age 56, an obese person's annual medical costs are higher than a smoker's, mostly because of problems that often come along with obesity, such as diabetes, arthritis and lower back pain. Healthy people have the lowest annual cost. But over a lifetime, the researchers calculated, healthy people incur the most cost, followed by the obese and then smokers, who die the earliest.

Does that mean we shouldn't try to get people to quit smoking or lose weight? Of course not, says Louise Russell, the "Is Prevention Better Than Cure?" author who is now a research professor at Rutgers University in New Jersey. "People are important, their health is important, and we want to make their lives better in a variety of ways," Russell said. "The point of the medical-care system is to serve people. It is not the point of people to serve the medical-care system." Prevention can be a great investment, but it's still an investment. Nothing in the modern health-care economy is cheap. Not even health.


Prince of Wales's guide to alternative medicine `inaccurate'

The Prince of Wales is being challenged today to withdraw two guides promoting alternative medicine, by scientists who say that they make misleading and inaccurate claims about its benefits. The documents, published by the Prince and his Foundation for Integrated Health, misrepresent scientific evidence about therapies such as homoeopathy, acupuncture and reflexology, say the authors of a new evaluation of alternative treatments.

In a letter to The Times, Edzard Ernst, Professor of Complementary Medicine at the University of Exeter, and Simon Singh, a science writer and broadcaster, call on the Prince to recall the publications, one of which was produced with a œ900,000 grant from the Department of Health. "They both contain numerous misleading and inaccurate claims concerning the supposed benefits of alternative medicine," they say. "The nation cannot be served by promoting ineffective and sometimes dangerous alternative treatments."

Professor Ernst and Dr Singh say the Prince accepted the importance of "rigorous scientific evidence" to alternative medicine, in an article he wrote for The Times in 2000, and point out that more than 4,000 research studies have since been published. They analysed these studies and previous research for their new book, Trick or Treatment: Alternative Medicine on Trial, finding that only a few treatments, such as some herbal medicines and acupuncture for pain relief, are backed up by the evidence that the Prince demanded. "The majority of alternative therapies appear to be clinically ineffective and many are downright dangerous," the letter says, and it calls on the Prince to withdraw the publications Complementary Health Care: A Guide for Patients and the Smallwood report.

The first document is a pamphlet, part-funded by the taxpayer, that gives advice on finding practitioners of alternative therapies. It is misleading, Professor Ernst said, because it includes disorders for which alternative remedies have been shown to be ineffective. It states, for example, that chi-ropractic is used to treat asthma, digestive disorders and migraine, when it has been shown by rigorous trials only to be useful for back pain. The guide also promotes acupuncture for addiction, when studies suggest that it has no benefit, and homoeopathy, which a major review for The Lancet has indicated works only as a placebo. "It explains what these therapies are used for, and that carries an implication that they work when the evidence suggests that many do not," Professor Ernst said.

The foundation has already withdrawn some sections of the pamphlet from its website, such as a claim that research has shown healing to have benefits for some medical conditions. The Smallwood report, commissioned by the Prince from Christopher Smallwood, an economist, argued that greater provision of alternative medicine on the NHS could save taxpayers' money. A study in the British Medical Journal has shown that only five research projects have examined the cost-effectiveness of alternative medicine, and all but one found that greater provision would add to costs.

Professor Ernst was consulted by Mr Smallwood, but said that his criticisms were ignored. Sir Michael Peat, the Prince's private secretary, accused Professor Ernst of breaching confidence by discussing a draft of the report with The Times. Natasha Finlayson, of the Prince's Foundation for Integrated Health, said: "We entirely reject the accusation that our online publication Complementary Healthcare: A Guide contains any misleading or inaccurate claims about the benefits of complementary therapies. On the contrary, it treats people as adults and takes a responsible approach by encouraging people to look at reliable sources of information . . . so that they can make informed decisions. The foundation does not promote complementary therapies."

Claims and counters

A Guide for Patients Chiropractic: used in disorders of musculoskeletal system such as spine, neck, shoulder problems. It may also be used for asthma

Professor Ernst: no good evidence for anything other than back pain

Acupuncture: increasingly used in trying to overcome addictions to alcohol, drugs and smoking.

The reliable evidence suggests it does not work for addictions

Cranial therapists: the conditions they treat range from acute to chronic health problems

No good evidence for any of this

Homoeopathy: most often used to treat chronic conditions such as asthma; eczema; fatigue disorders; migraine; menopausal problems; irritable bowel syndrome; Crohn's disease; allergies; repeated infections; depression.

Data do not show homoeopathic remedies to be more than placebos

Reflexologists: work with conditions including pain, chronic fatigue, sinusitis, arthritis, digestive problems, stress-related disorders and menopausal symptoms.

No good evidence for any of this

Reiki: used for physical, mental and emotional conditions

There is no good evidence that Reiki is effective for any condition

Shiatsu: used for a wide range of conditions, from injuries to more general symptoms of poor health

No good evidence for any of this

The Smallwood report Phytodolor: recommended for treatment of UK arthritis patients.

This German preparation is not available in the UK

Manipulative therapies: offer advantages over conventional treatments for lower back pain.

A Cochrane review concludes that there is no evidence that this spinal therapy is superior to other standard treatments


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