Cloned cells kill skin cancer

More details here. Note that the patient was the only one of nine treated who benefited. The remission was in other words almost certainly random. I get a lot of skin cancers and about half of them regress spontaneously

DOCTORS have, for the first time, successfully treated a skin cancer patient with cells cloned from his own immune system, according to a new study. The ground-breaking treatment for advanced melanoma, or skin cancer, led to a long remission for the patient and used his own cloned infection-fighting T-cells, said doctor Cassian Yee, the lead author of the study in the New England Journal of Medicine.

Dr Yee and his associates from the Clinical Research Division at Fred Hutchinson Cancer Research Centre in Seattle removed CD4+ T-cells, a type of white blood cell, from a 52-year-old man whose melanoma had spread to a groin lymph node and to one of his lungs. The melanoma was already well advanced and in stage four.

The T-cells which specifically fight melanoma were modified and expanded in the laboratory and some five billion cells were then infused into the patient, who received no other kind of treatment. Two months later no tumours were found during scans of the patient's organs. And he had been cancer-free for two years, Dr Yee said. "We were surprised by the anti-tumour effect of these CD4 T cells and its duration of response,'' Dr Yee said. "For this patient we were successful, but we would need to confirm the effectiveness of therapy in a larger study.''

It was the first ever case to show that cloned cells from a patient's own immune system could successful combat skin cancer. If further tests confirmed the efficiency of the method, it could be used in some 25 per cent of patients with late-stage skin cancer, the study said.

Using a patient's own immune system to combat cancer, called immunotherapy, is a growing area of research that aims to develop less-toxic cancer treatments than standard chemotherapy and radiation.

Some 160,000 cases of melanoma are diagnosed around the world every year, particularly affecting white men living in very sunny regions. Although it usually affects the skin, in rare cases it can also infect the eyes and intestines. According to the World Health Organisation, some 48,000 people die from melanoma every year.

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Quite amazing: Obesity illegal in Japan

Japan, a country not known for its overweight people, has undertaken one of the most ambitious campaigns ever by a nation to slim down its citizenry

Summoned by the city of Amagasaki one recent morning, Minoru Nogiri, 45, a flower shop owner, found himself lining up to have his waistline measured. With no visible paunch, he seemed to run little risk of being classified as overweight, or metabo, the preferred word in Japan these days. But because the new state-prescribed limit for male waistlines is a strict 33.5 inches, he had anxiously measured himself at home a couple of days earlier. "I'm on the border," he said.

Under a national law that came into effect two months ago, companies and local governments must now measure the waistlines of Japanese people between the ages of 40 and 74 as part of their annual checkups. That represents more than 56 million waistlines, or about 44 percent of the entire population.

Those exceeding government limits - 33.5 inches for men and 35.4 inches for women, which are identical to thresholds established in 2005 for Japan by the International Diabetes Federation as an easy guideline for identifying health risks - and having a weight-related ailment will be given dieting guidance if after three months they do not lose weight. If necessary, those people will be steered toward further re-education after six more months.

To reach its goals of shrinking the overweight population by 10 percent over the next four years and 25 percent over the next seven years, the government will impose financial penalties on companies and local governments that fail to meet specific targets. The country's Ministry of Health argues that the campaign will keep the spread of diseases like diabetes and strokes in check.

The ministry also says that curbing widening waistlines will rein in a rapidly aging society's ballooning health care costs, one of the most serious and politically delicate problems facing Japan today. Most Japanese are covered under public health care or through their work. Anger over a plan that would make those 75 and older pay more for health care brought a parliamentary censure motion Wednesday against Prime Minister Yasuo Fukuda, the first against a prime minister in the country's postwar history.

But critics say that the government guidelines - especially the one about male waistlines - are simply too strict and that more than half of all men will be considered overweight. The effect, they say, will be to encourage overmedication and ultimately raise health care costs.

Yoichi Ogushi, a professor at Tokai University's School of Medicine near Tokyo and an expert on public health, said that there was "no need at all" for the Japanese to lose weight. "I don't think the campaign will have any positive effect. Now if you did this in the United States, there would be benefits, since there are many Americans who weigh more than 100 kilograms," or about 220 pounds, Mr. Ogushi said. "But the Japanese are so slender that they can't afford to lose weight."

Mr. Ogushi was actually a little harder on Americans than they deserved. A survey by the National Center for Health Statistics found that the average waist size for Caucasian American men was 39 inches, a full inch lower than the 40-inch threshold established by the International Diabetes Federation. American women did not fare as well, with an average waist size of 36.5 inches, about two inches above their threshold of 34.6 inches. The differences in thresholds reflected variations in height and body type from Japanese men and women.

Comparable figures for the Japanese are sketchy since waistlines have not been measured officially in the past. But private research on thousands of Japanese indicates that the average male waistline falls just below the new government limit. That fact, widely reported in the media, has heightened the anxiety in the nation's health clinics.

In Amagasaki, a city in western Japan, officials have moved aggressively to measure waistlines in what the government calls special checkups. The city had to measure at least 65 percent of the 40- to 74-year-olds covered by public health insurance, an "extremely difficult" goal, acknowledged Midori Noguchi, a city official.

When his turn came, Mr. Nogiri, the flower shop owner, entered a booth where he bared his midriff, exposing a flat stomach with barely discernible love handles. A nurse wrapped a tape measure around his waist across his belly button: 33.6 inches, or 0.1 inch over the limit. "Strikeout," he said, defeat spreading across his face.

The campaign started a couple of years ago when the Health Ministry began beating the drums for a medical condition that few Japanese had ever heard of - metabolic syndrome - a collection of factors that heighten the risk of developing vascular disease and diabetes. Those include abdominal obesity, high blood pressure and high levels of blood glucose and cholesterol. In no time, the scary-sounding condition was popularly shortened to the funny-sounding metabo, and it has become the nation's shorthand for overweight.

The mayor of one town in Mie, a prefecture near here, became so wrapped up in the anti-metabo campaign that he and six other town officials formed a weight-loss group called "The Seven Metabo Samurai." That campaign ended abruptly after a 47-year-old member with a 39-inch waistline died of a heart attack while jogging.

Still, at a city gym in Amagasaki recently, dozens of residents - few of whom appeared overweight - danced to the city's anti-metabo song, which warned against trouser buttons popping and flying away, "pyun-pyun-pyun!" "Goodbye, metabolic. Let's get our checkups together. Go! Go! Go! Goodbye, metabolic. Don't wait till you get sick. No! No! No!"

The word metabo has made it easier for health care providers to urge their patients to lose weight, said Dr. Yoshikuni Sakamoto, a physician in the employee health insurance union at Matsushita, which makes Panasonic products. "Before we had to broach the issue with the word obesity, which definitely has a negative image," Dr. Sakamoto said. "But metabo sounds much more inclusive."

Even before Tokyo's directives, Matsushita had focused on its employees' weight during annual checkups. Last summer, Akio Inoue, 30, an engineer carrying 238 pounds on a 5-foot-7 frame, was told by a company doctor to lose weight or take medication for his high blood pressure. After dieting, he was down to 182 pounds, but his waistline was still more than one inch over the state-approved limit.

With the new law, Matsushita has to measure the waistlines of not only its employees but also of their families and retirees. As part of its intensifying efforts, the company has started giving its employees "metabo check" towels that double as tape measures. "Nobody will want to be singled out as metabo," Kimiko Shigeno, a company nurse, said of the campaign. "It'll have the same effect as non-smoking campaigns where smokers are now looked at disapprovingly."

Companies like Matsushita must measure the waistlines of at least 80 percent of their employees. Furthermore, they must get 10 percent of those deemed metabolic to lose weight by 2012, and 25 percent of them to lose weight by 2015.

NEC, Japan's largest maker of personal computers, said that if it failed to meet its targets, it could incur as much as $19 million in penalties. The company has decided to nip metabo in the bud by starting to measure the waistlines of all its employees over 30 years old and by sponsoring metabo education days for the employees' families.

Some experts say the government's guidelines on everything from waistlines to blood pressure are so strict that meeting, or exceeding, those targets will be impossible. They say that the government's real goal is to shift health care costs onto the private sector.

Dr. Minoru Yamakado, an official at the Japan Society of Ningen Dock, an association of doctors who administer physical exams, said he endorsed the government's campaign and its focus on preventive medicine. But he said that the government's real priority should be to reduce smoking rates, which remain among the highest among advanced nations, in large part because of Japan's powerful tobacco lobby. "Smoking is even one of the causes of metabolic syndrome," he said. "So if you're worried about metabo, stopping people from smoking should be your top priority."

Despite misgivings, though, Japan is pushing ahead. Kizashi Ohama, an official in Matsuyama, a city that has also acted aggressively against metabo, said he would leave the debate over the campaign's merits to experts and health officials in Tokyo.

At Matsuyama's public health clinic, Kinichiro Ichikawa, 62, said the government-approved 33.5-inch male waistline was "severe." He is 5-foot-4, weighs only 134 pounds and knows no one who is overweight. "Japan shouldn't be making such a fuss about this," he said before going off to have his waistline measured.

But on a shopping strip here, Kenzo Nagata, 73, a toy store owner, said he had ignored a letter summoning him to a so-called special checkup. His waistline was no one's business but his own, he said, though he volunteered that, at 32.7 inches, it fell safely below the limit. He planned to disregard the second notice that the city was scheduled to mail to the recalcitrant. "I'm not going," he said. "I don't think that concerns me."

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