Thursday, December 18, 2008

Sarcasm used to diagnose dementia

I like this. I do use sarcasm on occasions so if ever I get misunderstood as a result, I might tell the thick one that he is demented. It would be as logical as a lot of the medical reasoning that I review on this blog

Sarcasm may be the lowest form of wit, but scientists are using it to diagnose dementia. Researchers at the University of New South Wales found that patients under the age of 65 suffering from frontotemporal dementia (FTD), the second most common form of dementia, cannot detect when someone is being sarcastic.

The study, described by its authors as groundbreaking, helps explain why patients with the condition behave the way they do and why, for example, they are unable to pick up their caregivers' moods, the research showed. "This is significant because if care-givers are angry, sad or depressed, the patient won't pick this up. It is often very upsetting for family members," said John Hodges, the senior author of the paper published in Brain.

''(FTD) patients present changes in personality and behaviour. They find it difficult to interact with people, they don't pick up on social cues, they lack empathy, they make bad judgements,'' he said. "People with FTD become very gullible and they often part with large amounts of money," he said, adding that one in 4000 people around the world are afflicted with the condition.

Researchers began studying the role of sarcasm in detecting FTD because it requires a patient to spot discrepancies between a person's words and the tone of their voice, Mr Hodges said. "One of the things about FTD patients is that they don't detect humour - they are very bad at double meaning and a lot of humour (other than sarcasm) is based on double meaning," he said.

The research, conducted in 2006-07, put 26 sufferers of FTD and 19 Alzheimer's patients through a test in which actors acted out different scenarios using exactly the same words. While in one scenario, the actors would deliver the lines sincerely, in others they would introduce a thick layer of sarcasm. Patients were then asked if they got the joke, Hodges said.

For example, if a couple were discussing a weekend away and the wife suggested bringing her mother, the husband might say: "Well, that's great, you know how much I like your mother, that will really make it a great weekend." When the same words were delivered sarcastically and then in a neutral tone, the joke was lost on FTD patients, while the Alzheimer's patients got it. "The patients with FTD are very literal and they take what is being said as genuine and sincere," Mr Hodges said.


Common mushroom shown to help beat disease in study

I gather that this was an in vitro (laboratory) study so generalizability to live humans cannot be assumed. The abstract is here.

MUSHROOMS could play an important role in the fight against cancer, according to research reported on by the International Journal of Oncology. The study evaluated extracts from edible mushrooms and their impact on human breast cancer and colon cancer cells. "In our study we demonstrate that an edible oyster mushroom inhibits the growth of breast and colon cancer cells without affecting the normal cells," US researcher Daniel Sliva said. "The mushroom inhibits intra-cellular signalling molecules in cancer cells. ''These molecules are over-active in cancer cells and responsible for their 'bad' behaviour."

Dr Sliva and Andrej Jedinak from Indiana University's Cancer Research Laboratory in Indianapolis reported on the potential medical benefits of common mushroom species in the December issue of the International Journal of Oncology. "Mushrooms generally contain a lot of natural compounds, for example polysaccharides, mainly beta-D-glucans, which can boost the positive immune response, and other natural molecules," Dr Sliva said. "We can scientifically demonstrate that, in addition to their culinary value, mushrooms have a natural potential to protect against a variety of diseases."

Dietitian Glenn Cardwell said the findings supported earlier studies, which had pointed to a wide range of potential health benefits, including anti-tumour effects, immune-system benefits and the presence of significant antioxidant and anti-microbial properties. "Consumers already know mushrooms are a delicious part of the balanced diet,'' he said. ''Research highlighting long-term health benefits provides even more good reasons to add mushrooms into their next meal."


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