Monday, March 01, 2010

Painkillers 'double risk of deafness' for men

The conclusions in the article below may be correct but they don't follow from the evidence. Who are these people who take lots of painkillers? Presumably people with various bodily malfunctions. That their hearing may be part of the pattern of malfunctions is not at all surprising. The pills may have nothing to do with it.

Men who regularly take over-the-counter painkillers are twice as likely to suffer hearing problems than those who don't, a study has shown. Researchers found that younger men are particularly at risk. Taking paracetamol at least twice a week doubles the risk of mild to severe deafness before the age of 50. Other painkillers, including aspirin and ibuprofen, are also linked to hearing loss, the American researchers found.

The findings have not shown that painkillers directly cause deafness, but the scientists say they add to the evidence of a connection between the two.

Doctors have long known that high doses of aspirin can cause temporary tinnitus - or ringing in the ears. However, low doses of the painkiller have been shown to protect against deafness caused by noise and antibiotics. And previous anecdotal evidence has suggested non-steroidal anti-inflammatory drugs (NSAIDS) such as ibuprofen can harm hearing in people.

For the latest findings, researchers from Harvard University, Boston, tracked the health and lifestyles of more than 26,000 men every two years for 18 years. The subjects were asked about their use of painkillers and whether they had hearing problems. By the end of the study, nearly 3,500 reported some type of hearing loss. Taking into account the age, weight, background and medical history of the men, the researchers established a link between hearing problems and common painkillers. Although the study did not look at women, the researchers believe painkiller use could have an effect on their hearing.

Men under 60 who took at least two aspirins every week were 33 per cent more likely to suffer hearing loss than men who took fewer than two aspirins, the study showed. It found no link for men aged 60 and over. Men under 50 who regularly took ibuprofen and other NSAIDS were 61 per cent more likely to have hearing problems, while those aged 50 to 59 were 32 per cent more likely to suffer. Those aged 60 and above had a 16 per cent higher chance of deafness.

But the biggest link was found in men under the age of 50 who regularly took paracetamol. They are 99 per cent more likely to suffer hearing problems. Men aged 50 to 59 who regularly took paracetamol were 38 per cent more likely to have hearing loss, while those aged 60 and over had a 16 per cent greater chance, the researchers report in The American Journal of Medicine. For all groups, regular use meant taking at least two painkillers a week over a long period. The longer the period, the greater risk of hearing loss, it was found.

Dr Sharon Curhan, an author of the study based at Brigham and Women's Hospital, Boston, said: 'Given the high prevalence of regular analgesic use and health and social implications of hearing impairment, this represents an important public health issue.'

The researchers admitted that although they found a connection, they have not shown that painkillers cause hearing problems. The researchers did not have any information on how much noise the men were exposed to did not ask why they took painkillers. However, the scientists say that the drugs may cause damage to part of the inner ear.


A Cure for Character

by George Will

Peter De Vries, America's wittiest novelist, died 17 years ago but his discernment of this country's cultural foibles still amazes. In a 1983 novel, he spotted the tendency of America's therapeutic culture to medicalize character flaws:

"Once terms like identity doubts and midlife crisis become current," De Vries wrote, "the reported cases of them increase by leaps and bounds." And: "Rapid-fire means of communication have brought psychic dilapidation within the reach of the most provincial backwaters, so that large metropolitan centers and educated circles need no longer consider it their exclusive property, nor preen themselves on their special malaises."

Life is about to imitate De Vries' literature, again. The fourth edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM), psychiatry's encyclopedia of supposed mental "disorders," is being revised. The 16 years since the last revision evidently were prolific in producing new afflictions. The revision may aggravate the confusion of moral categories.

Today's DSM defines "oppositional defiant disorder" as a pattern of "negativistic, defiant, disobedient and hostile behavior toward authority figures." Symptoms include "often loses temper," "often deliberately annoys people" or "is often touchy." DSM omits this symptom: "is a teenager."

This DSM defines as "personality disorders" attributes that once were considered character flaws. "Antisocial personality disorder" is "a pervasive pattern of disregard for ... the rights of others ... callous, cynical ... an inflated and arrogant self-appraisal." "Histrionic personality disorder" is "excessive emotionality and attention-seeking." "Narcissistic personality disorder" involves "grandiosity, need for admiration ... boastful and pretentious." And so on.

If every character blemish or emotional turbulence is a "disorder" akin to a physical disability, legal accommodations are mandatory. Under federal law, "disabilities" include any "mental impairment that substantially limits one or more major life activities"; "mental impairments" include "emotional or mental illness." So there might be a legal entitlement to be a jerk. (See above, "antisocial personality disorder.")

The revised DSM reportedly may include "binge eating disorder" and "hypersexual disorder" ("a great deal of time" devoted to "sexual fantasies and urges" and "planning for and engaging in sexual behavior"). Concerning children, there might be "temper dysregulation disorder with dysphoria."

This last categorization illustrates the serious stakes in the categorization of behaviors. Extremely irritable or aggressive children are frequently diagnosed as bipolar and treated with powerful antipsychotic drugs. This can be a damaging mistake if behavioral modification treatment can mitigate the problem.

Another danger is that childhood eccentricities, sometimes inextricable from creativity, might be labeled "disorders" to be "cured." If 7-year-old Mozart tried composing his concertos today, he might be diagnosed with attention-deficit hyperactivity disorder and medicated into barren normality.

Furthermore, intellectual chaos can result from medicalizing the assessment of character. Today's therapeutic ethos, which celebrates curing and disparages judging, expresses the liberal disposition to assume that crime and other problematic behaviors reflect social or biological causation. While this absolves the individual of responsibility, it also strips the individual of personhood, and moral dignity.

James Q. Wilson, America's pre-eminent social scientist, has noted how "abuse excuse" threatens the legal system and society's moral equilibrium. Writing in National Affairs quarterly ("The Future of Blame"), Wilson notes that genetics and neuroscience seem to suggest that self-control is more attenuated -- perhaps to the vanishing point -- than our legal and ethical traditions assume.

The part of the brain that stimulates anger and aggression is larger in men than in women, and the part that restrains anger is smaller in men than in women. "Men," Wilson writes, "by no choice of their own, are far more prone to violence and far less capable of self-restraint than women." That does not, however, absolve violent men of blame. As Wilson says, biology and environment interact. And the social environment includes moral assumptions, sometimes codified in law, concerning expectations about our duty to desire what we ought to desire.

It is scientifically sensible to say that all behavior is in some sense caused. But a society that thinks scientific determinism renders personal responsibility a chimera must consider it absurd not only to condemn depravity but also to praise nobility. Such moral derangement can flow from exaggerated notions of what science teaches, or can teach, about the biological and environmental roots of behavior.

Or -- revisers of the DSM, please note -- confusion can flow from the notion that normality is always obvious and normative, meaning preferable. And the notion that deviations from it should be considered "disorders" to be "cured" rather than stigmatized as offenses against valid moral norms.


No comments: