Multivitamin link to breast cancer

Another nasty one for the health freaks. The absolute risk involved is small but such weak effects underpin most dietary advice.

The study is utter rubbish anyway. 1). It's based on self-reports; 2). It commits the "correlation is causation" fallacy. WHY were some women taking supplements? Probably because they felt less healthy anyway.

The abstract is here. The title of the article is "Multivitamin use and breast cancer incidence in a prospective cohort of Swedish women"

WOMEN who take a daily multivitamin pill are nearly 20 per cent more likely to develop breast cancer, a major study has revealed. The shock finding has rattled Australia's $2.5 billion complementary health industry, which is urging consumers not to panic.

In a 10-year study of more than 35,000 women, researchers discovered those who regularly took a multi-vitamin pill increased the risk of developing a tumour by 19 per cent.

They said the result was concerning and needed investigation as many women used multi-vitamins in the belief they prevented chronic diseases such as cancer.

A "biologically plausible" explanation was that taking vitamin and mineral supplements significantly increased the density of breast tissue, a strong risk factor for breast cancer. Folic acid, often present in a potent form in multi-vitamins, may also accelerate tumour growth.

Breast cancer is the most common cancer among females in Australia, affecting more than 12,000 and killing more than 2,700 women every year. One in nine women will be diagnosed with it by the age of 85.

The study, conducted by Sweden's Karolinska Institute and published in the American Journal of Clinical Nutrition, has been greeted with interest and caution by Australian experts.

Women who took a multivitamin pill in the study had higher breast tissue density than those who took no vitamin supplements. "Results from this prospective study suggest that the use of multivitamins may increase the risk of breast cancer," the lead author of the study, Susanna Larrson, said.

Multi-vitamins are big business in Australia, with leading maker Blackmores posting a before-tax profit of $30.6 million last financial year. Some nutritionists and dietitians argue supplements are unnecessary, as people absorb nutrients far better from food.

Kathy Chapman, of the Cancer Council Australia, told The Sunday Telegraph the study would add to a growing body of evidence that multi-vitamins were "not all they're cracked up to be". [Like you die earlier from taking them]

"It reinforces the importance of eating fresh fruit and vegetables rather than people thinking they can get more of their nutrition from a pill," she said. "What we've learned over time in cancer is that quick fixes aren't a good idea." Taking a multi-vitamin pill was linked to a smaller increase in breast cancer risk than being overweight or drinking too much alcohol, she said.

The Complementary Healthcare Council of Australia said "consumers need not panic" at the findings. It cited "concerns over limitations to the study", such as its reliance on self-administered questionnaires and failure to look at the bioactivity of multi-vitamin ingredients.

Blackmores advised customers "not to be alarmed" by the study, which it claims is inconclusive and conflicts with other research.

Professor John Boyages, director of the Westmead Breast Cancer Institute and spokesman for the National Breast Cancer Foundation, said he "wouldn't put any weight" on the study, as there were many complicated risk factors involved in breast cancer.

Delaying pregnancy until the age of 35, drinking alcohol every day and early-onset periods may each raise the risk by as much as 30 per cent, he said.

Nutrition Australia (NA) advocates getting vitamins and minerals from a varied diet rather than supplements. "Your body will absorb vitamins and minerals so much better from food," NA dietician Nicole Frederiksen said.

SOURCE






Antibody hunts, kills prostate cancer

Rather amazing news. Let's hope it passes double-blind studies in people

US RESEARCHERS have found an antibody that hunts down prostate cancer cells in mice and can destroy the killer disease even in an advanced stage.

The antibody, called F77, was found to bond more readily with cancerous prostate tissues and cells than with benign tissue and cells and to promote the death of cancerous tissue, a study published in the Proceedings of the National Academy of Science found.

When injected in mice, F77 bonded with tissue where prostate cancer was the primary cancer in almost all cases (97 per cent) and in tissue cores where the cancer had metastasised around 85 per cent of the time.

It recognised even androgen-independent cancer cells, present when prostate cancer is incurable, the study by researchers at the University of Pennsylvania showed.

F77 "initiated direct cell death of prostate cancer cells ... and effectively prevented tumour outgrowth,'' it said.

But it did not target normal tissue, or tumor tissues in other parts of the body including the colon, kidney, cervix, pancreas, lung, skin or bladder, the study showed.

The antibody "shows promising potential for diagnosis and treatment of prostate cancer, especially for androgen-independent metastatic prostate cancer", which often spread to the bones and was difficult to treat, the researchers wrote.

The five-year survival rate for metastatic prostate cancer was just 34 per cent, according to the study.

Prostate cancer is the second most common cancer among men, claiming half a million lives each year worldwide, according to the World Health Organisation.

SOURCE