Wednesday, January 16, 2013

Could a chocolate a day prevent pre-eclampsia?

Researchers are trying to test the theory that consuming small amounts of dark chocolate can reduce the risk of women developing the condition pre-eclampsia during pregnancy.

From next month, 100 pregnant women in Canberra, Cairns and Atherton will be given 25 grams of dark chocolate every day, up until 36 weeks of pregnancy.

A control group will not be given the dark chocolate but will also have their pregnancies followed.

Researcher and Canberra obstetrician and gynaecologist Professor Steve Robson said consuming dark chocolate was associated with a decrease in cardiovascular disease and it was hoped it could also help prevent pre-eclampsia.

“Nobody has ever been able to prevent or stop pre-eclampsia from coming on and they've tried all sorts of things over the years," Professor Robson said.

Pre-eclampsia affects about 10 per cent of pregnant women and can cause a rise in blood pressure and swelling of the feet, fingers and face.  More serious symptoms can include damage to the mother's kidneys, liver, brain and heart and interfere with the growth of the baby.  It can lead to life-threatening eclampsia, which causes the mother to have fits.

Taking part in the study should not be considered an excuse to pig out on chocolate.

Professor Robson said the dark chocolate issued to women would represent five per cent of their recommended daily fat intake.

“It would be bad news if on the one hand eating chocolate every day reduced the risk of getting hypertension and pre-eclampsia, but on the other hand put up your risk of getting diabetes. So we want to make sure it's not a give with one hand and a take with the other," he said.

Professor Robson said an initial pilot study would examine issues such as whether morning sickness prevented women from consuming dark chocolate.

The study is being conducted by James Cook University and the researchers have deliberately not sought funding from chocolate companies.


Anti-oxidants are BAD for you

 Scientists at The University of Manchester have made a surprising finding after studying how tadpoles re-grow their tails which could have big implications for research into human healing and regeneration.

It is generally appreciated that frogs and salamanders have remarkable regenerative capacities, in contrast to mammals, including humans. For example, if a tadpole loses its tail a new one will regenerate within a week. For several years Professor Enrique Amaya and his team at The Healing Foundation Centre in the Faculty of Life Sciences have been trying to better understand the regeneration process, in the hope of eventually using this information to find new therapies that will improve the ability of humans to heal and regenerate better.

In an earlier study, Professor Amaya's group identified which genes were activated during tail regeneration. Unexpectedly, that study showed that several genes that are involved in metabolism are activated, in particular those that are linked to the production of reactive oxygen species (ROS) -- chemically reactive molecules containing oxygen. What was unusually about those findings is that ROS are commonly believed to be harmful to cells.

Professor Amaya and his group decided to follow up on this unexpected result and their new findings will be published in the next issue of Nature Cell Biology.

To examine ROS during tail regeneration, they measured the level of H2O2 (hydrogen peroxide, a common reactive oxygen species in cells) using a fluorescent molecule that changes light emission properties in the presence of H2O2. Using this advanced form of imaging, Professor Amaya and his group were able to show that a marked increase in H2O2 occurs following tail amputation and interestingly, they showed that the H2O2 levels remained elevated during the entire tail regeneration process, which lasts several days.

Talking about the research Professor Amaya says: "We were very surprised to find these high levels of ROS during tail regeneration. Traditionally, ROS have been thought to have a negative impact on cells. But in this case they seemed to be having a positive impact on tail re-growth."

To assess how vital the presence of ROS are in the regeneration process, Professor Amaya's team limited ROS production using two methods. The first was by using chemicals, including an antioxidant, and the second was by removing a gene responsible for ROS production. In both cases the regeneration process was inhibited and the tadpole tail did not grow back.

Professor Amaya says: "When we decreased ROS levels, tissue growth and regeneration failed to occur. Our research suggests that ROS are essential to initiate and sustain the regeneration response. We also found that ROS production is essential to activate Wnt signalling, which has been implicated in essentially every studied regeneration system, including those found in humans. It was also striking that our study showed that antioxidants had such a negative impact on tissue regrowth, as we are often told that antioxidants should be beneficial to health."

The publication of Professor Amaya's study comes just days after a paper from the Nobel Prize winner and co-discoverer of the structure of DNA, James Watson, who has suggested antioxidants could be harmful to people in the later stages of cancer.

Professor Amaya comments: "It's very interesting that two papers suggesting that antioxidants may not always be beneficial have been published recently. Our findings and those of others are leading to a reversal in our thinking about the relative beneficial versus harmful effects that oxidants and antioxidants may have on human health, and indeed that oxidants, such as ROS, may play some important beneficial roles in healing and regeneration."

The next step for the team at the Healing Foundation Centre will be to study ROS and their role in the healing and regenerative processes more closely. With a better understanding,

Professor Amaya and his team hope to apply their findings to human health to identify whether manipulating ROS levels in the body could improve our ability to heal and regenerate tissues better. Thus these findings have very important implications in regenerative medicine.


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