Tuesday, February 25, 2014

Clean teeth can hold off arthritis: Scientists discover link between gum disease bacteria and early onset of the condition

On close reading, they do not appear to have discovered a link between teeth and arthritis.  They have just found that the two share a bacterium

Brushing your teeth well could help prevent arthritis, scientists claim.  Researchers found a link between the bacterium responsible for gum disease and earlier onset of rheumatoid arthritis, as well as faster progression and greater severity of the condition.

The bacterium produces an enzyme which reacts with the residue of certain proteins.

The body recognises these proteins as intruders, leading to an immune attack, the researchers from the University of Louisville’s School of Dentistry in Kentucky said.

In arthritis patients, the subsequent result is chronic inflammation responsible for bone and cartilage destruction within the joints.

Previous studies have indicated that gum disease is at least two times  more prevalent in rheumatoid arthritis patients.

The bacterium, Porphyromonas gingivalis, produces a unique enzyme, peptidylarginine deiminanse (PAD).

They discovered that PAD changes residues of certain proteins into citrulline, and the body recognises these proteins as intruders, leading to an immune attack.

In rheumatoid arthritis patients, the subsequent result is chronic inflammation responsible for bone and cartilage destruction within the joints.

Researcher Dr Jan Potempa from the University of Louisville School of Dentistry Oral Health and Systemic Diseases said: 'Taken together, our results suggest that bacterial PAD may constitute the mechanistic link between P. gingivalis periodontal infection and rheumatoid arthritis, but this ground-breaking conclusion will need to be verified with further research.'

Dr Potempa and his team studied another oral bacterium, Prevotella intermedia for the same affect, but learned it did not produce PAD or the subsequent effects.

Writing in the study, published in PLOS Pathogens, Dr Potempa said he is hopeful these findings will shed new light on the treatment and prevention of rheumatoid arthritis.

Studies indicate that compared to the general population, people with periodontal disease have an increased prevalence of rheumatoid arthritis and periodontal disease is at least two times more prevalent in rheumatoid arthritis patients.

Other research has shown that a P. gingivalis infection in the mouth will precede rheumatoid arthritis and the bacterium is the likely culprit for onset and continuation of the autoimmune inflammatory responses that occur in the disease.


IVF children are just as healthy and smart as those conceived normally

And that is the usual finding  -- despite attempts by haters to generate alarm

CHILDREN conceived using assisted reproductive technology (ART) grow to be as healthy and achieve similar educational outcomes to those conceived normally.

A new study comparing adult’s born through reproductive technologies, such as IVF, with non-ART adults found only minor differences between the groups.

ART babies are at increased risk of preterm birth, low birth weight and being small for gestational age. The study’s authors wanted to check whether this led to poorer physical health as they developed.

While the research found the ART group were twice as likely to be admitted to hospital in the first 18 years of life, it was not for serious illness.

“There were increased frequencies of dental extractions, tonsillectomies, hernia repairs and testicular erosion,” said the Murdoch Children’s Institute study.

However, the authors explain the discrepancy as “increased parental vigilance associated with perceived vulnerability in a much-wanted baby”.

The ART adults had an increased risk of asthma and hay fever, were slightly more likely to develop Type 1 diabetes, polycystic ovary syndrome and lactose intolerance, says the research published in the journal Fertility and Sterility on Thursday.

However, the study concludes “we found little evidence of significant health disparities”.

A significant increase in attention hyperactivity disorder in ART offspring disappeared when the study accounted for the significance of male gender in the study.

There was no evidence of any difference in autism, speech or learning difficulties or in sexual maturation between the two groups.

Around 80 per cent of both groups completed Year 12 and there was no significant difference in their tertiary entrance scores.

By the time they reached their mid-to-late twenties 48 per cent of ART offspring had completed tertiary education compared to 41 per cent in the non-ART group.

“Most have grown into healthy young adults, with a quality of life and educational achievements similar to their non-ART conceived peers,” the study concludes.

Candice Reed, the first child conceived using ART in Australia, was born in 1980 and many of the children born using this method are now adults.

This study tracked 656 Victorian mothers who used ART and their 547 young adult offspring aged between 18 and 29 years.

It compared their outcomes to reports from 868 mothers and their 549 young adult offspring who were conceived without ART.

Around 3.8 per cent of Australian mothers use ART to help them conceive and every year over 30,000 babies conceived in this way are born.

More than 4.3 million children around the world have been conceived using the technology.


1 comment:

Anonymous said...

Porphyromonas gingivalis, being an anaerobic bacteria as is the cavity producing streptococcus mutans which the sweetener xylitol kills, I wonder if xylitol intake may also influence arthritis? Probably not, but possibly.