Cutting back on fry-ups 'reduces risk of dementia': Study finds

If you are a mouse.  More information about the study here

A ‘compelling’ study has linked compounds found in fried meat and eggs with one of the hallmarks of Alzheimer’s disease.

Bacon is particularly problematic and the suspect chemicals are also found in many cakes, biscuits and pastries.

The researchers said that reducing intake could help prevent the crippling condition – and may even help restore memory that has been lost.

The research, from Mount Sinai School of Medicine in New York, focused on compounds called advanced glycation end products, or AGEs.

They are formed when fat, protein and sugar react on being heated and are found in particularly high levels in bacon, sausages, pizzas and burgers.

Frying and grilling is particularly bad, while boiling does not lead to them being made.

The researchers tracked the progress of a group of mice fed food containing levels of AGEs proportional to those in a Western diet and another group fed half the amount of the compound.

Their calorie intake was the same but only the mice on the AGE-rich diet suffered problems with memory, learning and co-ordination as they get older.

They also made less of an anti-ageing protein and their brains contained beta-amyloid, a sticky protein considered a hallmark of Alzheimer’s.

Results of experiments on people were similarly striking.  Tests on healthy pensioners showed that only those who had high amounts of AGEs in their diet became more forgetful over the coming months.  [Small correlational study only]

More work is needed but the researchers said cutting back on the compounds might help improve mental sharpness and ‘combat the epidemic’ of Alzheimer’s disease.

Tom Dening, professor of dementia research at Nottingham University, said that the studies needed to prove that cutting back on AGEs helps prevent Alzheimer’s would be lengthy.

He said: ‘In the meantime, crunch those carrots and reach for the brown rice.’

Professor Derek Hill, of University College London, said: ‘These results are compelling.  Because cures for Alzheimer’s disease remain a distant hope, efforts to prevent it are extremely important.’

Professor Simon Lovestone, of Oxford University, said that the solution will not be as simple as cutting back on one type of food and eating more of another.

Instead, he hopes that learning more about what goes wrong in the body and brain will lead to new drugs.

Dr Simon Ridley, of Alzheimer’s Research UK, said: ‘This research is at an early stage, and continued investment in research is crucial to understand the significance of results like this.

‘The diseases that cause dementia are complex, and our risk of the condition is likely to be affected by a number of genetic and environmental factors that are not yet fully understood.

‘In the meantime, the best evidence suggests that a balanced diet can help lower the risk of Alzheimer’s, as part of a healthy lifestyle that includes regular exercise, not smoking, and keeping blood pressure and weight in check.’

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Whole Foods: America’s Temple of Pseudoscience

Americans get riled up about creationists and climate change deniers, but lap up the quasi-religious snake oil at Whole Foods. It’s all pseudoscience—so why are some kinds of pseudoscience more equal than others?

If you want to write about spiritually-motivated pseudoscience in America, you head to the Creation Museum in Kentucky. It’s like a Law of Journalism. The museum has inspired hundreds of book chapters and articles (some of them, admittedly, mine) since it opened up in 2007. The place is like media magnet. And our nation’s liberal, coastal journalists are so many piles of iron fillings.

But you don’t have to schlep all the way to Kentucky in order to visit America’s greatest shrine to pseudoscience. In fact, that shrine is a 15-minute trip away from most American urbanites.

I’m talking, of course, about Whole Foods Market. From the probiotics aisle to the vaguely ridiculous Organic Integrity outreach effort (more on that later), Whole Foods has all the ingredients necessary to give Richard Dawkins nightmares. And if you want a sense of how weird, and how fraught, the relationship between science, politics, and commerce is in our modern world, then there’s really no better place to go. Because anti-science isn’t just a religious, conservative phenomenon—and the way in which it crosses cultural lines can tell us a lot about why places like the Creation Museum inspire so much rage, while places like Whole Foods don’t.

My own local Whole Foods is just a block away from the campus of Duke University. Like almost everything else near downtown Durham, N.C., it’s visited by a predominantly liberal clientele that skews academic, with more science PhDs per capita than a Mensa convention.

Still, there’s a lot in your average Whole Foods that’s resolutely pseudoscientific. The homeopathy section has plenty of Latin words and mathematical terms, but many of its remedies are so diluted that, statistically speaking, they may not contain a single molecule of the substance they purport to deliver. The book section—yep, Whole Foods sells books—boasts many M.D.’s among its authors, along with titles like The Coconut Oil Miracle and Herbal Medicine, Healing, and Cancer, which was written by a theologian and based on what the author calls the Eclectic Triphasic Medical System.

You can buy chocolate with “a meld of rich goji berries and ashwagandha root to strengthen your immune system,” and bottles of ChlorOxygen chlorophyll concentrate, which “builds better blood.” There’s cereal with the kind of ingredients that are “made in a kitchen—not in a lab,” and tea designed to heal the human heart.

Whenever we talk about science and society, it helps to keep in mind that very few of us are anywhere near rational.
Nearby are eight full shelves of probiotics—live bacteria intended to improve general health. I invited a biologist friend who studies human gut bacteria to come take a look with me. She read the healing claims printed on a handful of bottles and frowned. “This is bullshit,” she said, and went off to buy some vegetables. Later, while purchasing a bag of chickpeas, I browsed among the magazine racks. There was Paleo Living, and, not far away, the latest issue of What Doctors Don’t Tell You. Pseudoscience bubbles over into anti-science. A sample headline: “Stay sharp till the end: the secret cause of Alzheimer’s.” A sample opening sentence: “We like to think that medicine works.”

At times, the Whole Foods selection slips from the pseudoscientific into the quasi-religious. It’s not just the Ezekiel 4:9 bread (its recipe drawn from the eponymous Bible verse), or Dr. Bronner’s Magic Soaps, or Vitamineral Earth’s “Sacred Healing Food.” It’s also, at least for Jewish shoppers, the taboos that have grown up around the company’s Organic Integrity effort, all of which sound eerily like kosher law.

There’s a sign in the Durham store suggesting that shoppers bag their organic and conventional fruit separately—lest one rub off on the other—and grind their organic coffees at home—because the Whole Foods grinders process conventional coffee, too, and so might transfer some non-organic dust. “This slicer used for cutting both CONVENTIONAL and ORGANIC breads” warns a sign above the Durham location’s bread slicer. Synagogue kitchens are the only other places in which I’ve seen signs implying that level of food-separation purity.

Look, if homeopathic remedies make you feel better, take them. If the Paleo diet helps you eat fewer TV dinners, that’s great—even if the Paleo diet is probably premised more on The Flintstones than it is on any actual evidence about human evolutionary history. If non-organic crumbs bother you, avoid them. And there’s much to praise in Whole Foods’ commitment to sustainability and healthful foods.

Still: a significant portion of what Whole Foods sells is based on simple pseudoscience. And sometimes that can spill over into outright anti-science (think What Doctors Don’t Tell You, or Whole Foods’ overblown GMO campaign, which could merit its own article). If scientific accuracy in the public sphere is your jam, is there really that much of a difference between Creation Museum founder Ken Ham, who seems to have made a career marketing pseudoscience about the origins of the world, and John Mackey, a founder and CEO of Whole Foods Market, who seems to have made a career, in part, out of marketing pseudoscience about health?

Well, no—there isn’t really much difference, if the promulgation of pseudoscience in the public sphere is, strictly speaking, the only issue at play. By the total lack of outrage over Whole Foods’ existence, and by the total saturation of outrage over the Creation Museum, it’s clear that strict scientific accuracy in the public sphere isn’t quite as important to many of us as we might believe. Just ask all those scientists in the aisles of my local Whole Foods.

So, why do many of us perceive Whole Foods and the Creation Museum so differently? The most common liberal answer to that question isn’t quite correct: namely, that creationists harm society in a way that homeopaths don’t. I’m not saying that homeopathy is especially harmful; I’m saying that creationism may be relatively harmless. In isolation, unless you’re a biologist, your thoughts on creation don’t matter terribly much to your fellow citizens; and unless you’re a physician, your reliance on Sacred Healing Food to cure all ills is your own business.

The danger is when these ideas get tied up with other, more politically muscular ideologies. Creationism often does, of course—that’s when we should worry. But as vaccine skeptics start to prompt public health crises, and GMO opponents block projects that could save lives in the developing world, it’s fair to ask how much we can disentangle Whole Foods’ pseudoscientific wares from very real, very worrying antiscientific outbursts.

Still, we let it off the hook. Why? Two reasons come to mind. The first is that Whole Foods is a for-profit business, while the Creation Museum is the manifestation of an explicitly religious and political movement. For some reason, there’s a special stream of American rage directed at ideological attacks on science that seems to evaporate when the offender is a for-profit corporation.

It wasn’t especially surprising that Bill Nye would go and debate Ken Ham; it would have been unusual had he, say, challenged executives at the biotech company Syngenta—which has seemingly been running a smear campaign against a Berkeley biologist—to a conversation about scientific integrity, or challenged Paleo Magazine’s editors to a debate about archaeology. For those of us outside the fundamentalist world, I imagine that the Creation Museum gift shop is the one part of the museum that makes some kind of sense. Well, okay, they’re trying to make money with this stuff. Meanwhile, Whole Foods responds to its customers, as any good business should.

And, second, we often have it stuck in our heads that science communicators have only failed to speak to the religious right. But while issues of science-and-society are always tied up, in some ways, with politics, they’re not bound to any particular part of the spectrum. Just ask Robert F. Kennedy, Jr., liberal political scion and vaccine skeptic extraordinaire, or Prince Charles, who pushed British health ministers to embrace homeopathic medicine.

Bringing sound data into political conversations and consumer decisions is a huge, ongoing challenge. It’s not limited to one side of the public debate. The moral is not that we should all boycott Whole Foods. It’s that whenever we talk about science and society, it helps to keep two rather humbling premises in mind: very few of us are anywhere near rational. And pretty much all of us are hypocrites.

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